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DENDRITIC CELLS

Decrypting DC development

Nature Immunology volume 20, pages 1090–1092 (2019)Cite this article

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The NFIL3–ZEB2–ID2 transcription-factor regulatory circuit switches the E protein–dependent +41 kb Irf8 enhancer in DC progenitors to the BATF3-dependent +32 kb Irf8 enhancer in mature cDC1s. Deletion of the cryptic +41 kb Irf8 enhancer impedes cDC1 development.

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Fig. 1: Decrypting DC development through epistasis.

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Authors and Affiliations

  1. Laboratory of Myeloid Cell Ontogeny and Functional Specialization, VIB Center for Inflammation Research, Ghent, Belgium

    Martin Guilliams

  2. Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium

    Martin Guilliams

  3. Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Tomohiko Tamura

  4. Advanced Medical Research Center, Yokohama City University, Yokohama, Japan

    Tomohiko Tamura

Authors
  1. Martin Guilliams
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  2. Tomohiko Tamura
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Correspondence to Martin Guilliams or Tomohiko Tamura.

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The authors declare no competing interests.

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Guilliams, M., Tamura, T. Decrypting DC development. Nat Immunol 20, 1090–1092 (2019). https://doi.org/10.1038/s41590-019-0457-3

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