Conventional dendritic cells

Definition

Conventional dendritic cells (cDCs) are innate immune cells. The term cDC refers to all DCs other than plasmacytoid DCs. They reside in tissues and, following tissue infection or injury, they become activated and migrate to draining lymph nodes to promote adaptive immune responses.

Latest Research and Reviews

  • Research | | open

    Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunity.

    • Michel Enamorado
    • , Salvador Iborra
    • , Elena Priego
    • , Francisco J. Cueto
    • , Juan A. Quintana
    • , Sarai Martínez-Cano
    • , Ernesto Mejías-Pérez
    • , Mariano Esteban
    • , Ignacio Melero
    • , Andrés Hidalgo
    •  & David Sancho
  • Research |

    Cathepsin S is responsible for cleaving the invariant chain Ii for the presentation of peptides by major histocompatibility complex class II on DCs. Diamond and colleagues show that the transcription factor Blimp-1 negatively regulates expression of cathepsin S and influences selection of the TFH cell repertoire and autoantibody-producing B cells.

    • Sun Jung Kim
    • , Sebastian Schätzle
    • , S Sohail Ahmed
    • , Wolfgang Haap
    • , Su Hwa Jang
    • , Peter K Gregersen
    • , George Georgiou
    •  & Betty Diamond
  • Research |

    Prenatal immune suppression is regulated by fetal arginase-2-expressing dendritic cells which respond normally to toll-like receptor stimulation but, in contrast to adult dendritic cells, induce regulatory T cells and repress TNF-α secretion by effector T cells.

    • Naomi McGovern
    • , Amanda Shin
    • , Gillian Low
    • , Donovan Low
    • , Kaibo Duan
    • , Leong Jing Yao
    • , Rasha Msallam
    • , Ivy Low
    • , Nurhidaya Binte Shadan
    • , Hermi R Sumatoh
    • , Erin Soon
    • , Josephine Lum
    • , Esther Mok
    • , Sandra Hubert
    • , Peter See
    • , Edwin Huang Kunxiang
    • , Yie Hou Lee
    • , Baptiste Janela
    • , Mahesh Choolani
    • , Citra Nurfarah Zaini Mattar
    • , Yiping Fan
    • , Tony Kiat Hon Lim
    • , Dedrick Kok Hong Chan
    • , Ker-Kan Tan
    • , John Kit Chung Tam
    • , Christopher Schuster
    • , Adelheid Elbe-Bürger
    • , Xiao-nong Wang
    • , Venetia Bigley
    • , Matthew Collin
    • , Muzlifah Haniffa
    • , Andreas Schlitzer
    • , Michael Poidinger
    • , Salvatore Albani
    • , Anis Larbi
    • , Evan W Newell
    • , Jerry Kok Yen Chan
    •  & Florent Ginhoux
    Nature 546, 662–666
  • Research | | open

    Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are resistant to collagen-induced arthritis, whereas DCs from patients with rheumatoid arthritis have high levels of miR- 34a.

    • Mariola Kurowska-Stolarska
    • , Stefano Alivernini
    • , Emma Garcia Melchor
    • , Aziza Elmesmari
    • , Barbara Tolusso
    • , Clare Tange
    • , Luca Petricca
    • , Derek S. Gilchrist
    • , Gabriele Di Sante
    • , Chantal Keijzer
    • , Lynn Stewart
    • , Clara Di Mario
    • , Vicky Morrison
    • , James M. Brewer
    • , Duncan Porter
    • , Simon Milling
    • , Ronald D. Baxter
    • , David McCarey
    • , Elisa Gremese
    • , Greg Lemke
    • , Gianfranco Ferraccioli
    • , Charles McSharry
    •  & Iain B. McInnes

News and Comment

  • News and Views |

    Studies using genetic tools have identified the distinct dendritic cell subsets that ensure tolerance to oral antigens in the antigen-rich environment of the gut and suggest a 'division of labor' for protective immunity.

    • Reinhard Hinterleitner
    •  & Bana Jabri
    Nature Immunology 17, 474–476