The identification of T cells recognizing antigen has historically depended on live-cell imaging. Through the use of neural network–based image analysis, T cell–priming events can now be identified in fixed archival tissues.
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Spitzer, M.H. Hacking the ‘Cellular Immunology Agency’: T cells caught in the act. Nat Immunol 20, 382–383 (2019). https://doi.org/10.1038/s41590-019-0354-9
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DOI: https://doi.org/10.1038/s41590-019-0354-9