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INNATE LYMPHOID CELLS

Mysterious ILC2 tissue adaptation

Nature Immunology volume 19, pages 1042–1044 (2018)Cite this article

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Group 2 innate lymphoid cells (ILC2s) that produce the cytokine IL-5 are found in lung, gut, fat and skin tissues. New findings indicate that ILC2s in different tissues selectively express distinct functional cytokine receptors for cell activation in response to the local environment.

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Fig. 1: Tissue-specific signals regulate the expression of receptors for activating cytokines on ILC2s in different tissues.

References

  1. Artis, D. & Spits, H. Nature 517, 293–301 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Fang, D. & Zhu, J. J. Exp. Med. 214, 1861–1876 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ricardo-Gonzalez, R.R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0201-4 (2018).

  4. Huang, Y. et al. Science 359, 114–119 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Simoni, Y. et al. Immunity 46, 148–161 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. Nakanishi, K. Front. Immunol. 9, 763 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Guo, L., Junttila, I. S. & Paul, W. E. Trends Immunol. 33, 598–606 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ohne, Y. et al. Nat. Immunol. 17, 646–655 (2016).

    Article  CAS  PubMed  Google Scholar 

  9. Kim, B. S. et al. Sci. Transl. Med. 5, 170ra116 (2013).

    Article  CAS  Google Scholar 

  10. Salimi, M. et al. J. Exp. Med. 210, 2939–2950 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Robinette, M. L. et al. Nat. Immunol. 16, 306–317 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Yagi, R. et al. Immunity 40, 378–388 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Jinfang Zhu

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  1. Jinfang Zhu
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Correspondence to Jinfang Zhu.

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The author declares no competing interests.

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Zhu, J. Mysterious ILC2 tissue adaptation. Nat Immunol 19, 1042–1044 (2018). https://doi.org/10.1038/s41590-018-0214-z

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