Adult human kidney organoids or tubuloids are derived from an epithelial CD24+ subpopulation in the proximal nephron and can be utilized for advanced disease modeling of the most common hereditary kidney disease: autosomal dominant polycystic kidney disease.
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References
Schutgens, F. et al. Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nat. Biotechnol. 37, 303–313 (2019). This paper reports the generation of adult human kidney organoids or tubuloids.
Bergmann, C. et al. Polycystic kidney disease. Nat. Rev. Dis. Primers 4, 50 (2018). A Review article that presents an overview of polcystic kidney diseases.
Clevers, H. Modeling development and disease with organoids. Cell 165, 1586–1597 (2016). A Review article that presents an overview of organoids across major organs.
Kim, J. et al. Human organoids: model systems for human biology and medicine. Nat. Rev. Mol. Cell Bio. 21, 571–584 (2020). A Review article that presents an overview about organoid technologies across major organs.
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This is a summary of: Xu, Y. et al. Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease. Nat. Genet. https://doi.org/10.1038/s41588-022-01202-z (2022).
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Adult human kidney organoids: cellular origin and disease modeling. Nat Genet 54, 1593–1594 (2022). https://doi.org/10.1038/s41588-022-01207-8
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DOI: https://doi.org/10.1038/s41588-022-01207-8
