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Applied immunology

Antibiotic nanoparticles boost antitumor immunity

Nature Biotechnology (2023)Cite this article

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Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T cell immunity.

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Fig. 1: Antibiotics-loaded liposomes kill intratumoral bacteria and elicit antitumor T cell immunity.

References

  1. Wang, M. L. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01957-8 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kuai, R., Ochyl, L. J., Bahjat, K. S., Schwendeman, A. & Moon, J. J. Nat. Mater. 16, 489–496 (2017).

    Article  CAS  Google Scholar 

  3. Zamora, A. E., Crawford, J. C. & Thomas, P. G. J. Immunol. 200, 392–399 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. Galeano Niño, J. L. et al. Nature 611, 810–817 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kalaora, S. et al. Nature 592, 138–143 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Naghavian, R. et al. Nature 617, 807–817 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Nejman, D. et al. Science 368, 973–980 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Seynhaeve, A. L. B., Amin, M., Haemmerich, D., van Rhoon, G. C. & Ten Hagen, T. L. M. Adv. Drug Deliv. Rev. 163-164, 125–144 (2020).

    Article  CAS  PubMed  Google Scholar 

  9. Riquelme, E. et al. Cell 178, 795–806.e12 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author notes

  1. These authors contributed equally: Kai Han, Young Seok Cho.

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA

    Kai Han, Young Seok Cho & James J. Moon

  2. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China

    Kai Han

  3. Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA

    Kai Han, Young Seok Cho & James J. Moon

  4. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

    James J. Moon

Authors
  1. Kai Han
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  2. Young Seok Cho
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  3. James J. Moon
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Corresponding author

Correspondence to James J. Moon.

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Competing interests

J.J.M. declares financial interests for board membership, as a paid consultant, for research funding, and/or as an equity holder in EVOQ Therapeutics and Saros Therapeutics.

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Han, K., Cho, Y.S. & Moon, J.J. Antibiotic nanoparticles boost antitumor immunity. Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02046-6

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