Bladder cancer molecular subtypes are promising for predicting patient outcomes. In contrast to most reports to date that used unsupervised clustering methods, a new study has demonstrated the value of a tumour differentiation signature based on normal biological expression patterns characteristic of basal or differentiated urothelial cells.
Refers to Mo, Q. et al. Prognostic power of a tumour differentiation gene signature for bladder urothelial carcinomas. J. Natl Cancer Inst. https://doi.org/10.1093/jnci/djx243 (2018)
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The authors thank G. M. Dancik and T. C. M. Zuiverloon for their helpful suggestions and review of this article.
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Jones, R.T., Theodorescu, D. Two methods of prediction signatures. Nat Rev Urol 15, 340–342 (2018). https://doi.org/10.1038/s41585-018-0004-2
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DOI: https://doi.org/10.1038/s41585-018-0004-2
