Genomic analysis

Definition

Genomic analysis is the identification, measurement or comparison of genomic features such as DNA sequence, structural variation, gene expression, or regulatory and functional element annotation at a genomic scale. Methods for genomic analysis typically require high-throughput sequencing or microarray hybridization and bioinformatics.

Latest Research and Reviews

  • Research | | open

    Single-cell genomics can be used to study uncultured microorganisms. Here, Stepanauskas et al. present a method combining improved multiple displacement amplification and FACS, to obtain genomic sequences and cell size information from uncultivated microbial cells and viral particles in environmental samples.

    • Ramunas Stepanauskas
    • , Elizabeth A. Fergusson
    • , Joseph Brown
    • , Nicole J. Poulton
    • , Ben Tupper
    • , Jessica M. Labonté
    • , Eric D. Becraft
    • , Julia M. Brown
    • , Maria G. Pachiadaki
    • , Tadas Povilaitis
    • , Brian P. Thompson
    • , Corianna J. Mascena
    • , Wendy K. Bellows
    •  & Arvydas Lubys
  • Research | | open

    Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

    • M. Carola Zillikens
    • , Serkalem Demissie
    • , Yi-Hsiang Hsu
    • , Laura M. Yerges-Armstrong
    • , Wen-Chi Chou
    • , Lisette Stolk
    • , Gregory Livshits
    • , Linda Broer
    • , Toby Johnson
    • , Daniel L. Koller
    • , Zoltán Kutalik
    • , Jian’an Luan
    • , Ida Malkin
    • , Janina S. Ried
    • , Albert V. Smith
    • , Gudmar Thorleifsson
    • , Liesbeth Vandenput
    • , Jing Hua Zhao
    • , Weihua Zhang
    • , Ali Aghdassi
    • , Kristina Åkesson
    • , Najaf Amin
    • , Leslie J. Baier
    • , Inês Barroso
    • , David A. Bennett
    • , Lars Bertram
    • , Rainer Biffar
    • , Murielle Bochud
    • , Michael Boehnke
    • , Ingrid B. Borecki
    • , Aron S. Buchman
    • , Liisa Byberg
    • , Harry Campbell
    • , Natalia Campos Obanda
    • , Jane A. Cauley
    • , Peggy M. Cawthon
    • , Henna Cederberg
    • , Zhao Chen
    • , Nam H. Cho
    • , Hyung Jin Choi
    • , Melina Claussnitzer
    • , Francis Collins
    • , Steven R. Cummings
    • , Philip L. Jager
    • , Ilja Demuth
    • , Rosalie A. M. Dhonukshe-Rutten
    • , Luda Diatchenko
    • , Gudny Eiriksdottir
    • , Anke W. Enneman
    • , Mike Erdos
    • , Johan G. Eriksson
    • , Joel Eriksson
    • , Karol Estrada
    • , Daniel S. Evans
    • , Mary F. Feitosa
    • , Mao Fu
    • , Melissa Garcia
    • , Christian Gieger
    • , Thomas Girke
    • , Nicole L. Glazer
    • , Harald Grallert
    • , Jagvir Grewal
    • , Bok-Ghee Han
    • , Robert L. Hanson
    • , Caroline Hayward
    • , Albert Hofman
    • , Eric P. Hoffman
    • , Georg Homuth
    • , Wen-Chi Hsueh
    • , Monica J. Hubal
    • , Alan Hubbard
    • , Kim M. Huffman
    • , Lise B. Husted
    • , Thomas Illig
    • , Erik Ingelsson
    • , Till Ittermann
    • , John-Olov Jansson
    • , Joanne M. Jordan
    • , Antti Jula
    • , Magnus Karlsson
    • , Kay-Tee Khaw
    • , Tuomas O. Kilpeläinen
    • , Norman Klopp
    • , Jacqueline S. L. Kloth
    • , Heikki A. Koistinen
    • , William E. Kraus
    • , Stephen Kritchevsky
    • , Teemu Kuulasmaa
    • , Johanna Kuusisto
    • , Markku Laakso
    • , Jari Lahti
    • , Thomas Lang
    • , Bente L. Langdahl
    • , Lenore J. Launer
    • , Jong-Young Lee
    • , Markus M. Lerch
    • , Joshua R. Lewis
    • , Lars Lind
    • , Cecilia Lindgren
    • , Yongmei Liu
    • , Suzanne Satterfield
    • , Alena Stančáková
    • , Stuart H. Ralston
    • , Veikko Salomaa
    • , Henry Völzke
    • , Natasja M. Schoor
    • , Robert N. Luben
    • , Bruce M. Psaty
    • , Tamara B. Harris
    • , Ruth J. F. Loos
    • , Emmi Tikkanen
    • , Unnur Thorsteinsdottir
    • , Youfang Liu
    • , Karin M. A. Swart
    • , Sian-Tsung Tan
    • , H.-Erich Wichman
    • , Braxton D. Mitchell
    • , Munro Peacock
    • , Arjun Verma
    • , Jaakko Tuomilehto
    • , Vilmundur Gudnason
    • , Jaspal S. Kooner
    • , Jean Wactawski-Wende
    • , Jerome I. Rotter
    • , Dawn Waterworth
    • , Tian Liu
    • , Claes Ohlsson
    • , Thomas Meitinger
    • , André G. Uitterlinden
    • , Jeffrey R. O’Connell
    • , Ozren Polasek
    • , Igor Rudan
    • , Andrew P. Morris
    • , Katri Räikkönen
    • , Ben A. Oostra
    • , Nicholas J. Wareham
    • , William Maixner
    • , Laura Scott
    • , Angela Döring
    • , Mark A. Tarnopolsky
    • , James F. Wilson
    • , Simon Melov
    • , Patricia Thompson
    • , Elisabeth Steinhagen-Thiessen
    • , Jian Shen
    • , Nicole Soranzo
    • , Michael N. Weedon
    • , Elizabeth A. Streeten
    • , Chan Soo Shin
    • , Gregory J. Tranah
    • , Eric S. Orwoll
    • , Weijia Xie
    • , John A. Robbins
    • , Sabine Schipf
    • , Yanhua Zhou
    • , Markus Perola
    • , Lei Yu
    • , Michael J. Econs
    • , Karl Michaëlsson
    • , John C. Chambers
    • , Peter Vollenweider
    • , Cynthia A. Thomson
    • , Annette Peters
    • , Östen Ljunggren
    • , Ryan Welch
    • , Anne Newman
    • , Aarno Palotie
    • , Dan Mellström
    • , Unnur Styrkarsdottir
    • , Carolina Medina-Gomez
    • , Cornelia M. Duijn
    • , Nicole C. Wright
    • , Stephan Parker
    • , Mark Walker
    • , Håkan Melhus
    • , Elisabeth Widen
    • , Shad Smith
    • , Fiona E. McGuigan
    • , Joban Sehmi
    • , Douglas P. Kiel
    • , Mattias Lorentzon
    • , Samuli Ripatti
    • , David Karasik
    • , Gunnar Sigurdsson
    • , Carrie M. Nielson
    • , Leif Mosekilde
    • , Vicky Ossowski
    • , Kari Stefansson
    • , Richard L. Prince
    • , Timothy D. Spector
    • , Fernando Rivadeneira
    • , Frances M. K. Williams
    •  & Eric E. Schadt

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