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Autoimmunity

Immune tolerance of citrullinated peptides

Nature Reviews Rheumatology volume 20, pages 141–142 (2024)Cite this article

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Re-establishing tolerance to autoantigens is an important aim for the treatment of rheumatoid arthritis (RA). Immunization of HLA-DR4 transgenic mice with citrullinated self-antigens can induce immune tolerance, which suggests that such antigens could have a therapeutic role in anti-citrullinated peptide antibody-positive RA.

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Authors and Affiliations

  1. Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia

    Ranjeny Thomas

  2. Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA

    William H. Robinson

  3. VA Palo Alto Health Care System, Palo Alto, CA, USA

    William H. Robinson

Authors
  1. Ranjeny Thomas
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  2. William H. Robinson
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Correspondence to Ranjeny Thomas.

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Competing interests

R.T. reports issued patent 9,017,697 B2: 2006 surrounding technology for targeting dendritic cells for antigen-specific tolerance, and funding from CSL to UniQuest to develop antigen-specific immunotherapy in Sjögren syndrome. W.H.R. declares no competing interests.

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Thomas, R., Robinson, W.H. Immune tolerance of citrullinated peptides. Nat Rev Rheumatol 20, 141–142 (2024). https://doi.org/10.1038/s41584-024-01081-0

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