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A hypothalamic boost for neurogenesis

Nature Reviews Neuroscience volume 23, page 391 (2022)Cite this article

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Ongoing neural stem cell (NSC) proliferation has been reported in the adult hippocampal dentate gyrus (DG) of many species. In rodents, the proliferation of DG NSCs and their maturation into adult-born neurons (ABNs) is modulated by extrinsic factors that alter neural activity. A new paper by Li, Luo et al. points to a crucial role for neurons in the hypothalamic supramammillary nucleus (SuM) in the regulation of hippocampal neurogenesis in adult mice.

By combining virus-mediated tracing with electrophysiological recordings in brain slices, the authors showed that SuM neuron terminals in the SGZ lie close to the processes of rNSCs but not to those of type 2 progenitors. Optogenetic stimulation of SuM neuron terminals in the SGZ depolarized rNSCs, and this effect was attenuated by glutamate (but not GABA) receptor blockers.

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References

Original article

  • Li, Y.-D. et al. Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior. Nat. Neurosci. 25, 630–645 (2022)

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Related articles

  • Denoth-Lippuner, A. & Jessberger, S. Formation and integration of new neurons in the adult hippocampus. Nat. Rev. Neurosci. 22, 223–236 (2021)

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  1. Nature Reviews Neuroscience http://www.nature.com/nrn/

    Katherine Whalley

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  1. Katherine Whalley
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Correspondence to Katherine Whalley.

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Whalley, K. A hypothalamic boost for neurogenesis. Nat Rev Neurosci 23, 391 (2022). https://doi.org/10.1038/s41583-022-00607-3

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  • DOI: https://doi.org/10.1038/s41583-022-00607-3

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