Neural stem cells

Definition

Neural stem cells are multipotent adult stem cells present in the adult central nervous system that can self-renew, and give rise to new neurons and supporting cells called glial cells. Activation of neural stem cells or their transplantation into areas of central nervous system injury can lead to regeneration in animal models.

Latest Research and Reviews

  • Research |

    Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.

    • Fikri Birey
    • , Jimena Andersen
    • , Christopher D. Makinson
    • , Saiful Islam
    • , Wu Wei
    • , Nina Huber
    • , H. Christina Fan
    • , Kimberly R. Cordes Metzler
    • , Georgia Panagiotakos
    • , Nicholas Thom
    • , Nancy A. O’Rourke
    • , Lars M. Steinmetz
    • , Jonathan A. Bernstein
    • , Joachim Hallmayer
    • , John R. Huguenard
    •  & Sergiu P. Paşca
    Nature 545, 54–59
  • Research |

    The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems biology to discover underlying mechanisms in HD. They identify neurodevelopmental deficits in HD cells that can be corrected in cells and in vivo with a small molecule.

    • The HD iPSC Consortium
    • , Ryan G Lim
    • , Lisa L Salazar
    • , Daniel K Wilton
    • , Alvin R King
    • , Jennifer T Stocksdale
    • , Delaram Sharifabad
    • , Alice L Lau
    • , Beth Stevens
    • , Jack C Reidling
    • , Sara T Winokur
    • , Malcolm S Casale
    • , Leslie M Thompson
    • , Mónica Pardo
    • , A Gerardo García Díaz-Barriga
    • , Marco Straccia
    • , Phil Sanders
    • , Jordi Alberch
    • , Josep M Canals
    • , Julia A Kaye
    • , Mariah Dunlap
    • , Lisa Jo
    • , Hanna May
    • , Elliot Mount
    • , Cliff Anderson-Bergman
    • , Kelly Haston
    • , Steven Finkbeiner
    • , Amanda J Kedaigle
    • , Theresa A Gipson
    • , Ferah Yildirim
    • , Christopher W Ng
    • , Pamela Milani
    • , David E Housman
    • , Ernest Fraenkel
    • , Nicholas D Allen
    • , Paul J Kemp
    • , Ranjit Singh Atwal
    • , Marta Biagioli
    • , James F Gusella
    • , Marcy E MacDonald
    • , Sergey S Akimov
    • , Nicolas Arbez
    • , Jacqueline Stewart
    • , Christopher A Ross
    • , Virginia B Mattis
    • , Colton M Tom
    • , Loren Ornelas
    • , Anais Sahabian
    • , Lindsay Lenaeus
    • , Berhan Mandefro
    • , Dhruv Sareen
    •  & Clive N Svendsen
    Nature Neuroscience 20, 648–660
  • Research | | open

    The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.

    • Bart C. Jongbloets
    • , Suzanne Lemstra
    • , Roberta Schellino
    • , Mark H. Broekhoven
    • , Jyoti Parkash
    • , Anita J. C. G. M. Hellemons
    • , Tianyi Mao
    • , Paolo Giacobini
    • , Henriette van Praag
    • , Silvia De Marchis
    • , Geert M. J. Ramakers
    •  & R. Jeroen Pasterkamp

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