Apolipoprotein E (APOE) is the most abundant apolipoprotein in the brain, where it is primarily expressed and secreted by astrocytes and microglia. APOE seems to exert immunomodulatory effects in an isoform-dependent way, and a new study indicates that the APOE isoform dictates the glycosylation state and secretion of this apolipoprotein.
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Hasel, P., Liddelow, S.A. Isoform-dependent APOE secretion modulates neuroinflammation. Nat Rev Neurol 17, 265–266 (2021). https://doi.org/10.1038/s41582-021-00483-y
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DOI: https://doi.org/10.1038/s41582-021-00483-y
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