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Restoration of embryonic gene expression patterns in tissue regeneration and disease

Nature Reviews Molecular Cell Biology volume 24, pages 375–376 (2023)Cite this article

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Embryonic gene expression programmes are reactivated in response to various types of tissue damage in adult organs to provide cell plasticity and potency for regeneration. I propose that, depending on the extent of damage, being acute or chronic, adult cells restore their expression programmes to late or early embryonic states, respectively.

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References

  1. Fazilaty, H. et al. Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal damage. Cell Rep. 36, 109484 (2021).

    Article  CAS  PubMed  Google Scholar 

  2. Nusse, Y. M. et al. Parasitic helminthes induce fetal-like reversion in the intestinal stem cell niche. Nature 559, 109–113 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. LaCanna, R. et al. Yap/Taz regulate alveolar regeneration and resolution of lung inflammation. J. Clin. Invest. 129, 2107–2122 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Miao, Q. et al. SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair. Nat. Commun. 10, 4042 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Spanehl, L., Revskij, D., Bannert, K., Ehlers, L. & Jaster, R. YAP activates pancreatic stellate cells and enhances pancreatic fibrosis. Hepatobiliary & Pancreat. Dis. Int. 21, 583–589 (2022).

    Article  Google Scholar 

  6. Nieto, M. A., Huang, R. Y.-J., Jackson, R. A. & Thiery, J. P. EMT: 2016. Cell 166, 21–45 (2016).

    Article  CAS  PubMed  Google Scholar 

  7. Spike, B. T. et al. A mammary stem cell population identified and characterized in late embryogenesis reveals similarities to human breast cancer. Cell Stem Cell 10, 183–197 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gkountela, S. et al. Circulating tumor cell clustering shapes DNA methylation to enable metastasis seeding. Cell 176, 98–112 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Pastushenko, I. et al. Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis. Nature 589, 448–455 (2021).

    Article  CAS  PubMed  Google Scholar 

  10. Laughney, A. M. et al. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nat. Med. 26, 259–269 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

I am grateful to K. Basler for immense support, G. Hausmann for valuable comments on the manuscript, M. D. Brügger for technical assistance with the figure and other members of the Basler laboratory for discussions and feedbacks. My work was supported by the Forschungskredit of the University of Zürich grant FK-21-119 and a grant of the University and Medical Faculty of Zurich and the Comprehensive Cancer Center Zurich.

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  1. Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

    Hassan Fazilaty

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  1. Hassan Fazilaty
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Correspondence to Hassan Fazilaty.

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Nature Reviews Molecular Cell Biology thanks the anonymous reviewers for their contribution to the peer review of this work.

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Fazilaty, H. Restoration of embryonic gene expression patterns in tissue regeneration and disease. Nat Rev Mol Cell Biol 24, 375–376 (2023). https://doi.org/10.1038/s41580-023-00586-y

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