Regeneration articles from across Nature Portfolio

The cellular atlas of Pristina leidyi reveals cell type diversity in adult annelids by single cell transcriptomics, discovering several novel cell types and suggesting a pluripotent stem cell signature associated with adult cell type differentiation

This study uses single-cell transcriptomics to examine how lung cells respond to targeted damage. The authors employ genetically modified mouse models and cell sorting to enrich for rare, actively dividing cells, revealing cell types/states and alternative differentiation paths.

In this study, the authors have investigated if the implantation of fibrin gel loaded with platelet-rich plasma-derived exosomes is a feasible strategy to treat rotator cuff injuries. In fact, this strategy proved to promote tendon repair and healing outcomes in a rabbit model of rotator cuff injury.

Biotechnology firm LyGenesis has injected donor cells into a person with liver failure for the first time.

In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.

By analysing the effect of disrupting microbiota during in vivo reprogramming, Kovatcheva et al. demonstrated that vitamin B₁₂-dependent metabolism is a limiting factor for cellular reprogramming and plasticity, and propose its therapeutic supplementation for the improvement of tissue repair.

Yu et al. identify senescent cells as important players in the regeneration of complex structures.