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Health burden in cancer survivors: below the tip of the iceberg

In recent decades, cancer survival has improved dramatically, resulting in a growing population of cancer survivors with chronic health needs and disease risks. While large epidemiological studies are useful in tracking broad trends in health outcomes of cancer survivors, they lack the level of detail needed to inform the delivery of appropriate clinical care and optimal allocation of resources.

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Fig. 1: Age distribution for four common cancers in the USA, noting large number of older survivors.

References

  1. Bluethmann, S. M., Mariotto, A. B. & Rowland, J. H. Anticipating the “Silver Tsunami”: prevalence trajectories and comorbidity burden among older cancer survivors in the United States. Cancer Epidemiol. Biomarkers Prev. 25, 1029–1036 (2016).

    Article  Google Scholar 

  2. National Cancer Institute. Cancer stat facts: cancer of any site. SEER https://seer.cancer.gov/statfacts/html/all.html (2019).

  3. De Moor, J. S. et al. Cancer survivors in the United States: prevalence across the survivorship trajectory and implications for care. Cancer Epidemiol. Biomarkers Prev. 22, 541561–541570 (2013).

    Google Scholar 

  4. Oeffinger, K. C. et al. Chronic health conditions in adult survivors of childhood cancer. N. Engl. J. Med. 355, 1572–1582 (2006).

    Article  CAS  Google Scholar 

  5. Armstrong, G. T. et al. Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study. J. Clin. Oncol. 32, 1218–1227 (2014).

    Article  Google Scholar 

  6. Yabroff, K. R. et al. Burden of illness in cancer survivors: findings from a population-based national sample. J. Natl Cancer Inst. 96, 1322–1330 (2004).

    Article  Google Scholar 

  7. Kjaer, T. K. et al. Long-term somatic disease risk in adult Danish cancer survivors. JAMA Oncol. 5, 537–545 (2019).

    Article  Google Scholar 

  8. Blackburn, B. E. et al. Aging-related disease risks among young thyroid cancer survivors. Cancer Epidemiol. Biomarkers Prev. 26, 1695–1704 (2017).

    Article  Google Scholar 

  9. Park, J. et al. Risk factors for cardiovascular disease among thyroid cancer survivors: findings from the Utah Cancer Survivors Study. J. Clin. Endocrinol. Metab. 103, 2468–2477 (2018).

    Article  Google Scholar 

  10. Henderson, T. O., Ness, K. K. & Cohen, H. J. Accelerated aging among cancer survivors: from pediatrics to geriatrics. Am. Soc. Clin. Oncol. Educ. Book 34, e423–e430 (2014).

    Article  Google Scholar 

  11. Miller, K. D. et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J. Clin. 66, 271–289 (2016).

    Article  Google Scholar 

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Correspondence to Patricia A. Ganz.

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RELATED LINKS

SEER Medicare Database: https://healthcaredelivery.cancer.gov/seermedicare/

Evaluative Clinical Sciences Research Platform: https://sunnybrook.ca/research/content/?page=sri-platform-evaluativeclinicalsciences

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Brauer, E.R., Ganz, P.A. Health burden in cancer survivors: below the tip of the iceberg. Nat Rev Clin Oncol 16, 467–468 (2019). https://doi.org/10.1038/s41571-019-0226-0

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