Review Article | Published:

Well-defined nickel and palladium precatalysts for cross-coupling

Nature Reviews Chemistry volume 1, Article number: 0025 (2017) | Download Citation

Abstract

Transition metal-catalysed cross-coupling is one of the most powerful synthetic methods and has led to vast improvements in the synthesis of pharmaceuticals, agrochemicals and precursors for materials chemistry. A major advance in cross-coupling over the past 20 years is the utilization of well-defined, bench-stable Pd and Ni precatalysts that do not require the addition of free ancillary ligand, which can hinder catalysis by occupying open coordination sites on the metal. The development of precatalysts has resulted in new reactions and expanded substrate scopes, enabling transformations under milder conditions and with lower catalyst loadings. This Review highlights recent advances in the development of Pd and Ni precatalysts for cross-coupling, and provides a critical comparison between the state of the art in Pd- and Ni-based systems.

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Acknowledgements

N.H. acknowledges support from the National Institute of General Medical Sciences (NIHGMS) under Award Number R01GM120162. P.R.M. and M.M. thank the National Science Foundation (NSF) for support as NSF Graduate Research Fellows. The authors thank their co-workers and collaborators for their insight, which has shaped their view of the field.

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  1. The Department of Chemistry, Yale University, PO box 208107, New Haven, Connecticut 06520, USA.

    • Nilay Hazari
    • , Patrick R. Melvin
    •  & Megan Mohadjer Beromi

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https://doi.org/10.1038/s41570-017-0025