Synthetic chemistry methodology

Definition

Synthetic chemistry methodology refers to the methods used for the synthesis of chemical compounds.

Latest Research and Reviews

News and Comment

  • News and Views |

    A unique transformation for the site-selective cleavage of one C–C single bond and two C–H bonds in sequence has now been developed. This enables a simple carbon skeleton to be reorganized into a significantly more complex form with remarkable efficiency.

    • Masahiro Murakami
    •  & Naoki Ishida
    Nature Chemistry 9, 298–299
  • News and Views |

    Free radicals are notorious for unselective coupling reactions; however, the coupling of free radicals generated from acyl tellurides has now been shown to form C–C bonds with remarkable fidelity, which enables easy one-step assembly of densely oxygenated natural product motifs.

    • Wenhao Zhang
    •  & Ang Li
    Nature Chemistry 9, 198–199
  • News and Views |

    Nature oxidizes biosynthetic intermediates into structurally and functionally diverse peptides. An iron-catalysed C–H oxidation mimics this approach in the lab, enabling chemists to synthesize structural analogues with ease.

    • Sean Bartlett
    •  & David R. Spring
  • Comments and Opinion |

    As compared to the drug discovery process, the development of new 18F PET tracers lacks a well-established pipeline that advances compounds from academic research to candidacy for (pre)clinical imaging. In order to bridge the gaps between methodological advances and clinical success, we must rethink the development process from training to implementation.

    • Michael G. Campbell
    • , Joel Mercier
    • , Christophe Genicot
    • , Véronique Gouverneur
    • , Jacob M. Hooker
    •  & Tobias Ritter
  • News and Views |

    Three different methods that use a single ruthenium catalyst to enable the facile formation of meta- and para-substituted alkenylarenes have now been developed. The reactions proceed through a tandem alkenylation/decarboxylation process and provide several advantages over alternative approaches.

    • Marco Simonetti
    •  & Igor Larrosa
    Nature Chemistry 8, 1086–1088
  • News and Views |

    Despite their potential as drugs, peptides are generally not cell permeable, which limits their practical applications in medicine. Now, linear peptides have been cyclized by using a heteroaromatic linker. This cyclization both improves passive membrane permeability and stabilizes a biologically relevant secondary structure.

    • Fumito Saito
    •  & Jeffrey W. Bode
    Nature Chemistry 8, 1085–1086