Cross-coupling reactions

Definition

Cross-coupling reactions are those in which two different starting materials, each of which is usually endowed with an activating group, are reacted together with the aid of a metal catalyst. The result is the loss of the two activating groups and the formation of a new covalent bond between the remaining fragments.

Latest Research and Reviews

News and Comment

  • News and Views |

    Cross-coupling between a racemic secondary alkyl halide and an alkyl borane to produce an enantioenriched alkyl–alkyl product is one of the final substrate combinations to succumb to the synthetically powerful Suzuki–Miyaura methodology.

    • Ben W. Glasspoole
    •  & Cathleen M. Crudden
    Nature Chemistry 3, 912–913
  • Editorial |

    The 2010 Nobel Prize for Chemistry rewards a family of techniques for forging carbon-carbon bonds that have already helped to create new organic materials.

  • News and Views |

    The stereochemical lability of cycloalkylzinc reagents combined with a large difference in reactivity between epimers has been exploited to form a wide variety of interesting organic compounds with both high yields and diastereoselectivities.

    • Frank Glorius
    Nature Chemistry 2, 78–80