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Fungal pathogenesis

Metabolic sensing tips the balance of drug tolerance in fungal meningitis

Nature Microbiology volume 9, pages 316–317 (2024)Cite this article

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Sensing of brain glucose by the fungal pathogen Cryptococcus neoformans alters lipid metabolism and membrane composition in the fungus, rendering it drug tolerant.

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Fig. 1: Glucose sensing alters Cryptococcus membrane composition leading to AmB tolerance.

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Authors and Affiliations

  1. Shmunis School of Biomedical and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel

    Austin Mottola & Judith Berman

  2. Berlin Institute of Health (BIH) at Charité – Universitätsmedizin Berlin, Berlin, Germany

    Johannes Hartl & Markus Ralser

  3. Charité – Universitätsmedizin Berlin, Department of Biochemistry, Berlin, Germany

    Markus Ralser

  4. The Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK

    Markus Ralser

  5. Max Planck Institute for Molecular Genetics, Berlin, Germany

    Markus Ralser

  6. Edmond J. Safra Center for Bioinformatics, Tel Aviv University, Ramat Aviv, Israel

    Judith Berman

Authors
  1. Austin Mottola
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  2. Johannes Hartl
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  3. Markus Ralser
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  4. Judith Berman
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Correspondence to Judith Berman.

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Competing interests

M.R. is a founder and a shareholder of Elitpca Ltd. All other authors declare no competing interests.

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Mottola, A., Hartl, J., Ralser, M. et al. Metabolic sensing tips the balance of drug tolerance in fungal meningitis. Nat Microbiol 9, 316–317 (2024). https://doi.org/10.1038/s41564-023-01595-5

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