Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BACTERIAL GENOMICS

An ‘i’ for ingenuity

Nature Microbiology volume 4, pages 1071–1072 (2019)Cite this article

Subjects

The rapidly dividing bacterium Vibrio natriegens holds promise for transforming traditional molecular biology and biotechnology processes. New work demonstrates that CRISPR interference technology is a robust tool for rapid, genome-wide screens in V. natriegens, facilitating future bioengineering efforts.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: V. natriegens growth, genome and genome-wide screen.

References

  1. Eagon, E. G. J. Bacteriol. 83, 736–737 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Lee, H. H. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-019-0423-8 (2019).

  3. Baba, T. et al. Mol Syst Biol. 2, 2006.0008 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Luo, H., Lin, Y., Gao, F., Zhang, C. T. & Zhang, R. Nucleic Acid Res. 42, 574–780 (2014).

    Article  CAS  Google Scholar 

  5. Posfai, G. et al. Science. 312, 1044–1046 (2006).

    Article  CAS  PubMed  Google Scholar 

  6. Hutchison, C. A. III Science. 351, aad6253 (2016).

    Article  PubMed  Google Scholar 

  7. Qi, L. S. et al. Cell. 152, 1173–1183 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Rock, J. M. et al. Nat Microbiol. 1, 160274 (2016).

    Google Scholar 

  9. Cui, L. et al. Nat. Commun. 9, 1912 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Zhang, S. & Voigt, C. A. Nucleic Acids Res. 46, 11115–11125 (2018).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Peters, J. M. et al. Cell. 165, 1493–1506 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Harmsen, H. J. M. et al. Int. J. Syst. Bacteriol. 48, 1383–1387 (1998).

    Article  CAS  PubMed  Google Scholar 

  13. Gill, W. P. et al. Nat Med. 15, 211–214 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Eley, A., Greenwood, D. & O’Grady, F. J. Med. Micro. 19, 195–201 (1985).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Microbiology, Harvard Medical School, Boston, MA, USA

    Jonathan D. D’Gama & Matthew K. Waldor

  2. Division of Infectious Diseases, Brigham & Women’s Hospital, Boston, MA, USA

    Jonathan D. D’Gama & Matthew K. Waldor

  3. Howard Hughes Medical Institute, Boston, MA, USA

    Matthew K. Waldor

Authors
  1. Jonathan D. D’Gama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Matthew K. Waldor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matthew K. Waldor.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

D’Gama, J.D., Waldor, M.K. An ‘i’ for ingenuity. Nat Microbiol 4, 1071–1072 (2019). https://doi.org/10.1038/s41564-019-0490-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41564-019-0490-x

Search

Advanced search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology