Genome-wide association studies and genetic analyses have identified a clinically prevalent alteration in the Mycobacterium tuberculosis genome that rewires bacterial propionate metabolism, conditionally reduces antibiotic killing without affecting minimum inhibitory concentrations, and may drive emergence of drug resistance.
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CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
Nature Microbiology Open Access 30 May 2022
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Dick, T., Dartois, V. TB drug susceptibility is more than MIC. Nat Microbiol 3, 971–972 (2018). https://doi.org/10.1038/s41564-018-0226-3
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DOI: https://doi.org/10.1038/s41564-018-0226-3