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Synthetic biology

Engineering yeast to produce plant-derived anti-obesity agent

Nature Chemistry volume 15, pages 1204–1205 (2023)Cite this article

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Plants produce a wide range of compounds with important bioactivities. Celastrol, an anti-obesity agent found in the root of certain plants, can now be produced de novo in yeast.

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Fig. 1: Engineered yeast can serve as chassis for the production of celastrol and other valuable bioactive compounds.

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Authors and Affiliations

  1. BioInnovation Institute, Copenhagen, Denmark

    Jens Nielsen

  2. Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden

    Jens Nielsen

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  1. Jens Nielsen
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Correspondence to Jens Nielsen.

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The author declares no competing interests.

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Nielsen, J. Engineering yeast to produce plant-derived anti-obesity agent. Nat. Chem. 15, 1204–1205 (2023). https://doi.org/10.1038/s41557-023-01292-0

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