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DISEASE MECHANOBIOLOGY

Stiffness triggers non-coding RNA pathology

Nature Biomedical Engineering volume 3, pages 85–86 (2019)Cite this article

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The stiffness associated with cardiac fibrosis activates the expression of a common genetic polymorphism associated with cardiac pathology.

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Fig. 1: Patient-specific CMs derived from iPSC-CMs are amenable to study the functional effects of a genetic risk factor for cardiovascular disease.

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Authors and Affiliations

  1. Frankel Cardiovascular Regeneration Core Laboratory, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI, USA

    Todd Joseph Herron

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  1. Todd Joseph Herron
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Correspondence to Todd Joseph Herron.

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Competing interests

T.J. Herron is a co-founder of CARTOX, LLC, a biotechnology company focused on using hiPSC-CMs for preclinical cardiotoxicity screening.

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Herron, T.J. Stiffness triggers non-coding RNA pathology. Nat Biomed Eng 3, 85–86 (2019). https://doi.org/10.1038/s41551-019-0352-0

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