Mechanotransduction

Definition

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses.

Latest Research and Reviews

  • Protocols |

    Mechanical forces can trigger a variety of biological responses in cells and tissues. This protocol describes how to combine 3D magnetic twisting cytometry with confocal fluorescence microscopy to study these force responses in greater detail.

    • Yuejin Zhang
    • , Fuxiang Wei
    • , Yeh-Chuin Poh
    • , Qiong Jia
    • , Junjian Chen
    • , Junwei Chen
    • , Junyu Luo
    • , Wenting Yao
    • , Wenwen Zhou
    • , Wei Huang
    • , Fang Yang
    • , Yao Zhang
    •  & Ning Wang
    Nature Protocols 12, 1437–1450
  • Reviews |

    Physical forces influence the growth and development of all organisms. In the second Review in the Series on Mechanobiology, Trepat and co-authors describe techniques to measure forces generated by cells, and discuss their use and limitations.

    • Pere Roca-Cusachs
    • , Vito Conte
    •  & Xavier Trepat
    Nature Cell Biology 19, 742–751
  • Research |

    Kronenberg et al. develop a system to record cell–substrate interactions allowing the measurement of horizontal and vertical forces at high resolution, and demonstrate its use by monitoring podosome protrusion and other cell behaviours.

    • Nils M. Kronenberg
    • , Philipp Liehm
    • , Anja Steude
    • , Johanna A. Knipper
    • , Jessica G. Borger
    • , Giuliano Scarcelli
    • , Kristian Franze
    • , Simon J. Powis
    •  & Malte C. Gather
    Nature Cell Biology 19, 864–872
  • Reviews |

    Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases.

    • Michael Potente
    •  & Taija Mäkinen
  • Research | | open

    Establishment of the outer blood-retina barrier is a hallmark of retinal development but the contribution of choroid endothelial cells (ECs) is not known. Here the authors show in the developing mouse retina that ECs remodel the basement membrane and lead to enhanced barrier function of retinal epithelial cells.

    • Ignacio Benedicto
    • , Guillermo L. Lehmann
    • , Michael Ginsberg
    • , Daniel J. Nolan
    • , Rohan Bareja
    • , Olivier Elemento
    • , Zelda Salfati
    • , Nazia M. Alam
    • , Glen T. Prusky
    • , Pierre Llanos
    • , Sina Y. Rabbany
    • , Arvydas Maminishkis
    • , Sheldon S. Miller
    • , Shahin Rafii
    •  & Enrique Rodriguez-Boulan
  • Research | | open

    The transcriptional co-activator YAP is known to operate downstream of mechanical signals arising from the cell niche. Here the authors demonstrate that YAP controls cell mechanics, force development and adhesion strength by promoting the transcription of genes related to focal adhesions.

    • Giorgia Nardone
    • , Jorge Oliver-De La Cruz
    • , Jan Vrbsky
    • , Cecilia Martini
    • , Jan Pribyl
    • , Petr Skládal
    • , Martin Pešl
    • , Guido Caluori
    • , Stefania Pagliari
    • , Fabiana Martino
    • , Zuzana Maceckova
    • , Marian Hajduch
    • , Andres Sanz-Garcia
    • , Nicola Maria Pugno
    • , Gorazd Bernard Stokin
    •  & Giancarlo Forte

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