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Effects of childhood and adolescence physical activity patterns on psychosis risk—a general population cohort study

  • npj Schizophrenia 3, Article number: 5 (2017)
  • doi:10.1038/s41537-016-0007-z
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Schizophrenia spectrum disorders are associated with high morbidity and mortality in somatic diseases. The risk factors of this excess mortality include, e.g., obesity, dietary factors, and physical inactivity, especially after the onset of psychosis, but there are limited early developmental data on these factors in individuals who later develop psychosis. A population-based cohort study “Cardiovascular Risk of Young Finns” started in 1980 with 3596 children and adolescents from six different age groups (3, 6, 9, 12, 15, and 18 years). Cardiovascular health parameters, including questionnaire of physical activity before first hospitalization (≤18 years), were studied in 1980, 1983, and 1986. All psychiatric diagnoses of the participants were derived from the Finnish Hospital Discharge Register up to the year 2012. We identified diagnostic groups of non-affective psychosis (n = 68, including a schizophrenia subgroup, n = 41), personality disorders (n = 43), affective disorders (n = 111), and substance-related disorders (n = 49), based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). Groups were compared with controls with no psychiatric diagnoses (n = 3325). Sex, age, body mass index, birth weight, non-preterm birth, and mother’s mental disorders were included in the statistical model. Low physical activity in childhood and adolescence (9–18 years) independently predicted later development of non-affective psychosis. Lower physical activity index (relative risk 1.26 [1.1–1.5]), lower level of common activity during leisure time (relative risk 1.71 [1.2–2.5]), and non-participation in sports competitions (relative risk 2.58 [1.3–5.3]) were associated with a higher risk for later non-affective psychosis (expressed as increase in relative risk per physical activity unit). The findings were even stronger for schizophrenia, but no such link was observed for other diagnoses. The cause of low physical activity in premorbid/prodromal phase is likely to be multifactorial, including deviant motor and cognitive development. The results provide a rationale for including exercise and physical activity interventions as a part of psychosis prevention programs.


Schizophrenia spectrum disorders are consistently associated with high excess in mortality compared with the general population.13 Higher amount of physical illnesses, e.g., cardiovascular and pulmonary diseases, and metabolic diseases,4 play a major role in the excessive morbidity and mortality in schizophrenia.2 Somatic health problems in this population are partly due to the illness itself as well as antipsychotic medication, but unhealthy lifestyle also plays a considerable role.5,6 Physical inactivity is an independent risk factor for cardiovascular disease mortality.7,8 An overall decrease in cardiovascular mortality rates in the general population has been observed, but people with serious mental illnesses are not fully keeping up with the same development,9 although in the Nordic countries this gap has actually diminished.10 It seems that the improved health of the general population does not fully benefit people with serious mental illnesses.1

People with psychotic illnesses, on average, have an unhealthy lifestyle, including low levels of physical activity11,12 and poor cardiorespiratory fitness.13 Low levels of physical activity are prominently observed in later stages of schizophrenia but have also been reported in three studies concerning adolescents who later develop psychosis.14,15,16 The benefits of physical activity and exercise interventions in treating depression are relatively well established.17 Recently conducted meta-analyses show improvement in cardiorespiratory fitness,18,19 clinical symptoms, quality of life, global functioning and depression20 with physical activity promotion and exercise in patients with schizophrenia. However, it seems that patients with psychosis might be partly resistant to improvement in health, such as body mass index (BMI) or weight reduction due to exercise.19,21,22

Wide structural brain abnormalities in schizophrenia have been well documented in earlier studies,23,24,25 and at least some of these changes have a neurodevelopmental origin. Recent reports suggest that exercise interventions in schizophrenia can induce structural and functional brain changes, such as the morphology of hippocampus,26 increased cerebral gray matter,27 and even improvement in brain connectivity.28 These findings lead us to hypothesize that physical activity and exercise will modify brain development and maturation also in childhood and adolescence.

Earlier research suggests that patients with psychosis or schizophrenia, on average, have a history of delayed motor development in childhood and adolescence,29,30,31 as well as delayed neurological and cognitive development.32,33 Non-participation in physical activities among children may partly be due to aberrant development in motor skills, seen in some patients, or other subtle premorbid cognitive or affective symptoms.34 Yet, no systematic research has previously been done concerning physical activity and exercise patterns in children and adolescents who later develop psychosis.

This study aimed to examine whether physical activity levels in childhood and adolescence independently predict later development of non-affective psychosis. An ongoing, population-based cohort study enabled us to (1) have repetitive measures of physical activity before and after puberty, and (2) to link these data with hospital discharge register information of non-affective psychoses and other psychiatric diagnoses that led to one or more hospital treatment periods.

Changes in physical activity of individuals who later develop psychosis might already be seen in childhood, years before the onset of psychosis or prodromal symptoms. If so, the findings would suggest a rationale for including suitable forms of exercise in treatment programs for early psychosis.


Physical activity level was lower among children and adolescents who later developed non-affective psychosis (Fig. 1a, b; Tables 1 and 2). One unit lower physical activity index (PAI) at the age of 9–18 years, adjusted with covariates, was associated with a 26% higher risk of any non-affective psychosis (Table 2). One unit lower common activity during leisure time was associated with a 71% higher risk, and non-participation in sports competition with a 158% higher risk.

Figure 1
Figure 1

Mean (95% CI) physical activity index (range 5–14) in children and adolescents at 9–18 years of age. Gray line = individuals who later developed any non-affective psychosis (a) schizophrenia (b) and black line = controls with no psychiatric diagnoses during the follow-up

Table 1: Physical activity in childhood and adolescence (9–18 years, during years 1980–1986) in the groups with later development of schizophrenia or any non-affective psychosis, and controls with no psychiatric diagnoses during follow-up years 1980–2012
Table 2: Childhood and adolescent characteristics measured at the age of 9–18 and their associations with the risk of later development of any non-affective psychosis or schizophrenia in 1980–2012

In the group of patients with schizophrenia, the results were even stronger. One unit lower PAI in childhood and adolescence was associated with a 43% increase in the risk of later development of schizophrenia. One unit lower common activity during leisure time was associated with a 76% higher risk, one unit lower intensity of physical activity with a 71% higher risk, and one unit lower frequency of participation in organized training with a 40% and non-participation in sports competitions with a 388% higher risk of later development of schizophrenia. Physical activity of either parent was not associated with the risk of future psychosis or schizophrenia. PAI in childhood and adolescence was not associated with other mental disorders at adult age (p > 0.05 in all analyses, Supplementary Table 2).

Mother’s mental disorders were associated with a 296% higher risk for later development of psychosis and a 354% higher risk of later schizophrenia in their offspring (Table 2). Mental disorder of either or both parents was associated with a 269% higher risk of psychosis and a 365% higher risk of schizophrenia (Table 2). Childhood and adolescence BMI as a continuous variable, birth weight, or non-preterm birth had no significant association with the risk for non-affective psychosis later in life in view of these data (p > 0.05).

In the sensitivity analyses, the associations of PAI and later psychosis or schizophrenia remained similar, despite the classification of BMI to underweight or overweight. As expected, underweight in childhood and/or adolescence increased the risk of psychosis to two-fold (relative risk (RR) [95% CI] 2.1 [1.1, 4.0]; p = 0.026), but the independent effect of PAI remained unchanged (1.2 [1.1, 1.4]; p = 0.010). Early underweight also seemed to increase the risk for schizophrenia but this did not reach statistical significance (p = 0.064). Overweight was not associated with the risk of later psychosis (p = 0.237).


The main finding of this study is that low physical activity level in children and adolescents is an independent predictor for development of non-affective psychosis. This pattern of low physical activity was evident throughout the 9–18 year age period with no major differences before and after puberty, which is considered to be one of the critical time periods in the development of non-affective psychoses. Low level of common activity during leisure time and non-participation in sports competitions were risk factors for non-affective psychoses. Also, low intensity of leisure-time activity and low frequency of participation in organized training were risk factors for schizophrenia in particular.

The observation period was confined to years 1980–1986 because the data collection was complete during this period and only partial in the later follow-up points. Also, the role of societal effects needs to be considered in the interpretation and relevance of the results. The role of social media as well as computer/video games in leisure-time activity in these age groups are expected to be relatively small in 1980s compared with those in the 2010s. Some reports on the time trends in 12–18-years-old youth’s physical activity in Finland between 1979 and 2005 suggest that there is no major change in overall physical activity, but participation in moderate to vigorous physical activity has slightly increased.35

It is well known that parents’ mental disorders are associated with a risk of psychosis. This was also the case in this study. In our study, BMI was slightly lower in individuals who would later have a diagnosis of non-affective psychosis. Underweight in childhood36 and adolescence37 is a known risk factor for schizophrenia. In line with the previous studies, early underweight was associated with the risk of non-affective psychosis in this sample. However, the association between low physical activity and the risk of non-affective psychosis remained unchanged when continuous variable BMI was substituted with a categorized “BMI”, i.e., underweight or overweight, as a covariate in the sensitivity analysis. These results support the view that low premorbid or prodromal physical activity is linked to risk of non-affective psychosis irrespective of BMI.

The causes of lower physical activity levels in the premorbid or prodromal period of non-affective psychoses are not fully understood, but are likely to be multifactorial. Earlier studies have shown that at least some patients, who will later develop schizophrenia, have deviant motor development in childhood.38,39,40 In 1990, Walker et al. reported a case series suggesting that individuals, who later went on to develop schizophrenia, could be differentiated from their healthy siblings before the age of eight based on observed behavior in home videos. Children, who would later develop schizophrenia, were found to be less responsive, have less eye contact and positive affect, as well as worse fine and gross motor coordination.29 Schizophrenia is known to associate with delayed motor development, e.g., delayed walking, by the age of two.30,32 This has also been seen in direct longitudinal measurements of motor performance in childhood, and motor deficits seem to be specific for non-affective psychoses.31 Another cohort study reported that patients with later development of schizophrenia reached all developmental milestones, particularly smiling, lifting head, sitting, crawling and walking, later than healthy controls or individuals who later developed a psychiatric disorder other than schizophrenia.33 Non-participation in physical activities among children could partly be due to limited development of motor skills and avoidance of exercise.34 It is, however, likely that a complex combination of deviant motor development, motivational and reward deficits, subtle affective problems, and difficulties in social interaction all contribute to lower interest in physical activities and in particular those forms requiring social skills.41

Physical activity as a part of the early interventions for psychoses

Regardless of the causes of lower physical activity levels in the premorbid/prodromal phases of non-affective psychoses, our results have relevance for pre-emptive psychiatry, and provide rationale for including exercise in early interventions of psychosis. Physical activity and exercise therapy in treating psychiatric disorders have been studied intensively during recent years. For example, physical activity and exercise in treating major depression is already supported by considerable evidence. A large Cochrane review shows that exercise has moderately greater effect in reducing symptoms of depression when compared with no treatment, placebo or active control interventions, such as relaxation or meditation.17 For example, the UK National Institute of Health and Clinical Excellence recommends structured exercise for the treatment of mild to moderate depression.

However, results on exercise intervention in treating schizophrenia have been inconsistent. Exercise interventions can reduce both positive and negative symptoms19 and improve clinical symptoms, quality of life, global functioning, depression,20 and even cognitive functioning42 in adult schizophrenia patients. One meta-analysis did not find improvements in negative or positive symptoms of schizophrenia, or the individual’s quality of life.21 Improvement in physical fitness by exercise intervention or promotion is shown by few recent meta-analyses.18,19 Nevertheless, exercise interventions were not effective in reducing BMI19,21 or weight21,22 in people with schizophrenia. It seems that exercise intervention is less effective for patients with psychosis compared with patients with depression. However, the benefits of physical activity in treating psychosis has been shown and one meta-analysis already presents practical strategies for physical activity promotion as a part of treatment.13 It is currently not known whether these exercise interventions could be more effective in earlier premorbid or prodromal phases of the illness.

Physical exercise and brain morphology

Structural brain abnormalities have been conclusively documented in schizophrenia, such as larger lateral and third ventricles as well as widespread reduction of gray matter in the neocortex and limbic areas.23,24,25 There are recent reports on the effects of exercise on brain morphology in schizophrenia. The results show that exercise therapy or cardiorespiratory fitness improvement is related to hippocampal enlargement,26 increased cerebral gray matter volume, and decreased volume in lateral and third ventricle in adult patients with schizophrenia.27 In addition, a recent diffusion tensor imaging study by Svatkova et al. showed that white matter integrity, in particular those tracts involved in motor functioning, was improved by an exercise intervention of 6 months.28

An intriguing, and also likely, possibility is that physical activity and exercise affect the development and maturation of the central nervous system. We now know that exercise increases neurogenesis in the limbic areas, especially in the dentate gyrus of the hippocampus.43,44 Neurogenesis also takes place in the subventricular zone where the newly formed neurons, at least partly, migrate to striatum,45,46 which is centrally involved in networks regulating movement and cognition. Clearly, more research is needed on the mechanisms of how exercise affects the brain in different phases of human development.

Strength and limitations

The subjects in this randomly selected population cohort were prospectively followed up from early childhood to young adulthood before evidence for any psychotic disorder. The psychiatric diagnoses in this observational study were derived from the hospital discharge register in Finland. The diagnostic validity for schizophrenia spectrum in register-based studies has been reported to be good,47,48 whereas the validity of other diagnoses has not been well studied. It is also clear that patients requiring hospital treatment in the other diagnostic groups represent more severe forms of these disorders. In our study, the number of patients who will develop psychosis, and especially schizophrenia, is relatively low. This is a limitation but the longitudinal design still makes this sample valuable.

Physical activity was measured by a self-report questionnaire. We have previously validated the physical activity questionnaire in an independent population by studying the link between relevant components of PAI (i.e., intensity, frequency), with the volume of movement assessed with accelerometers and the number of steps measured with pedometers. These studies show significant positive correlations,49 which is well in line with other similar studies.50 In addition, we have collected step data using validated pedometers in 1934 individuals from the Young Finns study population. Participants wore an Omron Walking Style One (Model HJ-152R-E) step counter for a period of 1 week. Similarly, as in the small validation study done in an independent population, significant correlations were seen between the number of steps and individual components of the PAI.49 Telama et al. showed a significant correlation between PAI and the bicycle ergometer test, carried out in a subsample of 102 subjects. Although it was shown in adult subjects, PAI in 1980, when subjects were 9–18 years old, also correlated significantly with the fitness test in 2001.51

Extensive and consistent follow-up data were available on exercise levels but also on several possible risk factors of schizophrenia, enabling covariate adjusted statistical analyses. The effect of exercise level on the risk of non-affective psychosis was still highly significant after adjustment of other risk factors, but it is still possible that the link may be explained by a factor not measured in this cohort study.


Study sample

The participants were derived from a population-based, epidemiologic follow-up study Cardiovascular Risk of Young Finns (YFS).52 A total of 4320 healthy Finnish children and adolescents in age cohorts of 3, 6, 9, 12, 15, and 18 were invited and 3596 (83%) participated in the first cross-sectional survey in 1980. The participants were randomly selected from the national register from five Finnish population centers (Helsinki, Turku, Tampere, Kuopio, and Oulu) and their rural surroundings. A full-scale follow-up of the original protocol was possible for 6 years, yielding follow-up data from the years 1980, 1983, and 1986 for children and adolescents aged 3–18 years, 6–21 years, and 9–24 years, respectively. Thereafter, there is a gap of 15 years in the 3-year follow-up schedule, except for minor substudies concerning only selected participant groups. The next follow-up for all participants took place in 2001, when even the youngest of participants were 24 years old. In the present study, only measurements from the first three follow-ups, from 1980 to 1986 up to the participants’ age of 18 years, were included. Thus, none of the subject data are complete from age 3 to 18, and for those born prior to 1968, there cannot be data from more than one or two visits due to the design of the study. As the number of participants is high and we have no reason to assume any remarkable differences between the birth cohorts, the follow-up series from the three study visits (1980–1986) including children and adolescents from six age points were combined for the analyses. From 50% of the 3596 participants, full data from all three study visits (1980–1986) were available. Of 25% of participants, data were available from two visits, and of 25% from one visit.

Psychiatric diagnoses of the participants (years 1980–2012) were obtained from the Finnish National Hospital Discharge Register, which is maintained by the National Institute for Health and Welfare in Finland. The register covers all general and mental hospitals in Finland since 1969, without gaps. ICD-diagnoses were converted to DSM-IV diagnoses (Supplementary Table 1). Diagnostic groups were formed, and subjects who had several psychiatric diagnoses were categorized under only one of the groups in the following order of priority: schizophrenia (DSM-IV 295) and all non-affective psychoses (DSM-IV 295, 297, 298), personality disorders (DSM-IV 301), affective disorders (mood and anxiety disorders, DSM-IV 296, 300, 311), and substance-related disorders (DSM-IV 291, 303, 292, 304, 305). Non-affective psychosis was diagnosed in 68 of the 3596 participants, 40 (59%) men and 28 (41%) women, resulting in a 1.9% prevalence of this class of psychoses in this population. In the group of non-affective psychosis, 41 (60%) of the subjects were diagnosed as having schizophrenia, schizophreniform disorder or schizoaffective disorder (DSM-IV 295), 5 (7%) had delusional disorder (DSM-IV 297), and 22 (32%) had brief psychotic disorder or psychotic disorder NOS (DSM-IV 298). The prevalence of schizophrenia was 1.1%. The youngest subject having the first hospital treatment for psychotic disorder was 18, which was used as a cut-off age for analysis of the premorbid/prodromal phase of psychosis. The mean (SD) age for receiving a hospital-related diagnosis for non-affective psychosis was 28.4 (7.0) years, being 28.2 (6.6) years among men and 28.7 (7.8) years among women. The prevalences for other psychiatric hospital-related diagnoses were 1.2% (n = 43) for personality disorders, 3.1% (n = 111) for affective disorders, and 1.4% (n = 49) for substance-related disorders.

The permissions to use register data and link diagnostic data to YFS data were acquired from the respective organizations. The protocol was approved by the Ethics Committee of the Hospital District of Southwest Finland.

Physical activity in childhood and adolescence

Physical activity was assessed with a self-report questionnaire for subjects aged 9, 12, 15, and 18. The questionnaire (Table 3) was administered individually during the study visits that included medical examinations. The questions included the frequency and intensity of leisure-time physical activity, participation in sports club training, participation in competitive sport events, and common activity during leisure time. The answers were coded from 1 to 3, with 1 representing inactivity or very low activity, 2 moderately intensive or frequent activity, and 3 frequent or vigorous activity. Answers to participation in competitive sport events were coded only from 1 to 2. The PAI was calculated as a sum of measurements in the aforementioned questions, with the ratings ranging from 5 to 14.53

Table 3: The assessment of physical activity and creation of the PAI in 1980–1986

Clinical characteristics of children and adolescents

Height and weight of the children and adolescents were measured and BMI was calculated as kg/m2. BMI was further dichotomized using the classification provided by Cole et al. to underweight vs. not underweight representing adult BMI ≤ 18.5 vs. higher54 and overweight vs. not overweight representing adult BMI ≥ 25 vs. lower.55 Birth weight was asked in 1983 and 1986 in a questionnaire for the participants’ parents.

Parental characteristics

Participants’ mothers were asked about parents’ mental disorders or problems, diagnosed by a doctor, with a self-report questionnaire in 1980 and 1983. Parents’ physical activity was asked about in the years 1986 and 1989 by asking whether a parent is engaged in regular physical activity (the answers were coded from 1 to 3, 1 = rarely or not at all, 2 = sometimes or with other hobbies, 3 = regularly). If a parent answered with option 3, the frequency of physical activity was also asked (answers were coded from 1 to 5, 1 = once a month or less, 2 = 2–3 times a month, 3 = once a week, 4 = 2–6 times a week, 5 = every day).

Statistical methods

The descriptive statistics are given as n (%) and mean (SD). Associations of childhood and adolescent physical activity with the risk of adult age psychosis are given as risk ratios with 95% confidence intervals (RR [95% CI]) from univariate and multivariable modified Poisson regression models.56 Generalized estimating equation estimation was used in analyses of repeated measures.57 The multivariable models included sex, age, BMI in childhood and adolescence, mother’s mental disorders, birth weight, and non-preterm birth as covariates. BMI and physical activity data were used from all available time points and analyzed longitudinally. Mother’s mental disorders were excluded from the model, including mental disorders of either parent. The potential confounding effect of BMI on the association of PAI and risk for psychosis or schizophrenia was further checked with sensitivity analyses, substituting BMI with underweight vs. not underweight and overweight vs. not overweight in the univariate and multivariate models. Statistical analyses were done using SAS® version 9.4 (SAS Institute, Cary, NC, USA).


We found that physical activity in childhood and adolescence is an independent risk factor for later development of non-affective psychosis. Further research is needed to assess the role and possibilities of early exercise and physical activity intervention as a part of psychosis prevention.


  1. 1.

    Saha, S., Chant, D. & Mcgrath, J. A systematic review of mortality in schizophrenia. Arch. Gen. Psychiatry 64, 1123–1131 (2007).

  2. 2.

    Olfson, M., Gerhard, T., Huang, C., Crystal, S. & Stroup, T. S. Premature mortality among adults with schizophrenia in the United States. JAMA Psychiatry 72, 1172–1181 (2015).

  3. 3.

    Walker, E. R., McGee, R. E. & Druss, B. G. Mortality in mental disorders and global disease burden implications. JAMA Psychiatry 72, 334 (2015).

  4. 4.

    Leucht, S., Burkard, T., Henderson, J., Maj, M. & Sartorius, N. Physical illness and schizophrenia: a review of the literature. Acta Psychiatr. Scand. 116, 317–333 (2007).

  5. 5.

    Correll, C. U. et al. Cardiometabolic risk in patients with first-episodeschizophrenia spectrum disorders baseline. JAMA Psychiatry 71, 1350–1363 (2014).

  6. 6.

    Salokangas, R. K. R. Medical problems in schizophrenia patients living in the community (alternative facilities). Curr. Opin. Psychiatry 20, 402–405 (2007).

  7. 7.

    Blair, S. N., Cheng, Y. & Holder, J. S. Is physical activity or physical fitness more important in defining health benefits? Med. Sci. Sports Exerc. 33, S379–S420 (2001).

  8. 8.

    Lee, I. M. & Skerrett, P. J. Physical activity and all-cause mortality: what is the dose-response relation? Med. Sci. Sports Exerc. 33, S459–S494 (2001).

  9. 9.

    Nolte, E. & McKee, C. M. Measuring the health of nations: updating an earlier analysis. Health Aff. 27, 58–71 (2008).

  10. 10.

    Wahlbeck, K., Westman, J., Nordentoft, M., Gissler, M. & Laursen, T. M. Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders. Br. J. Psychiatry 199, 453–458 (2011).

  11. 11.

    Daumit, G. L. et al. Physical activity patterns in adults with severe mental illness. J. Nerv. Ment. Dis. 193, 641–646 (2005).

  12. 12.

    Roick, C. et al. Health habits of patients with schizophrenia. Soc. Psychiatry Psychiatr. Epidemiol. 42, 268–276 (2007).

  13. 13.

    Vancampfort, D. et al. Promotion of cardiorespiratory fitness in schizophrenia: a clinical overview and meta-analysis. Acta Psychiatr. Scand. 132, 131–143 (2015).

  14. 14.

    Okkenhaug, A. et al. Physical activity in adolescents who later developed schizophrenia: a prospective case-control study from the young-HUNT. Nord. J. Psychiatry 70, 111–115 (2016).

  15. 15.

    Koivukangas, J. et al. Physical activity and fitness in adolescents at risk for psychosis within the Northern Finland 1986 birth cohort. Schizophr. Res. 116, 152–158 (2010).

  16. 16.

    Davidson, M. et al. Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am. J. Psychiatry 156, 1328–1335 (1999).

  17. 17.

    Cooney, G. et al. Exercise for depression (review). Cochrane Database Syst Rev. Issue 5. Art. No.:CD004366 (2013).

  18. 18.

    Vancampfort, D., Rosenbaum, S., Ward, P. B. & Stubbs, B. Exercise improves cardiorespiratory fitness in people with schizophrenia: a systematic review and meta-analysis. Schizophr. Res. 169, 453–457 (2015).

  19. 19.

    Firth, J., Cotter, J., Elliott, R., French, P. & Yung, A R. A systematic review and meta-analysis of exercise interventions in schizophrenia patients. Psychol. Med. 45, 1343–1361 (2015).

  20. 20.

    Dauwan, M., Begemann, M. J. H., Heringa, S. M. & Sommer, I. E. Exercise improves clinical symptoms, quality of life, global functioning, and depression in schizophrenia: a systematic review and meta-analysis. Schizophr. Bull. 42, 588–599 (2015).

  21. 21.

    Pearsall, R., Smith, D. J., Pelosi, A. & Geddes, J. Exercise therapy in adults with serious mental illness: a systematic review and meta-analysis. BMC Psychiatry 14, 117 (2014).

  22. 22.

    Krogh, J. et al. Can exercise increase fitness and reduce weight in patients with schizophrenia and depression? Front. Psychiatry 5, 89 (2014).

  23. 23.

    Hulshoff Pol, H. E. & Kahn, R. S. What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr. Bull. 34, 354–366 (2007).

  24. 24.

    Shenton, M. E., Dickey, C. C., Frumin, M. & McCarley, R. W. A review of MRI findings in schizophrenia. Schizophr. Res. 49, 1–52 (2001).

  25. 25.

    Wright, I. C. et al. Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiatry 157, 16–25 (2000).

  26. 26.

    Pajonk, F.-G. et al. Hippocampal plasticity in response to exercise in schizophrenia. Arch. Gen. Psychiatry 67, 133–143 (2010).

  27. 27.

    Scheewe, T. W. et al. Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls. Eur. Neuropsychopharmacol. 23, 675–685 (2013).

  28. 28.

    Svatkova, A. et al. Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. Schizophr. Bull. 41, 869–878 (2015).

  29. 29.

    Walker, E. & Lewine, R. J. Prediction of adult-onset schizophrenia from childhood home movies of the patients. Am. J. Psychiatry 147, 1052–1056 (1990).

  30. 30.

    Jones, P., Rodgers, B., Murray, R. & Marmot, M. Child development risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 19, 1398–1402 (1994).

  31. 31.

    Cannon, M. et al. Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch. Gen. Psychiatry 59, 449–456 (2002).

  32. 32.

    Isohanni, M. et al. Early developmental milestones in adult schizophrenia and other psychoses: a 31-year follow-up of the Northern Finland 1966 birth cohort. Schizophr. Res. 52, 1–19 (2001).

  33. 33.

    Sørensen, H. J. et al. Early developmental milestones and risk of schizophrenia: a 45-year follow-up of the copenhagen perinatal cohort. Schizophr. Res. 118, 41–47 (2010).

  34. 34.

    Gould, D. & Weiss, M. R. in Advanced in Pediatric Sport Sciences: Behavioural Issues (eds Gould, D., Weiss, M.) (Human Kinetics, 1987).

  35. 35.

    Nupponen, H., Laakso, L., Rimpelä, A., Pere, L. & Telama, R. Questionnaire-assessed moderate to vigorous physical activity of the Finnish youth in 1979–2005. Scand. J. Med. Sci. Sport 20, 1–7 (2010).

  36. 36.

    Wahlbeck, K., Forsén, T., Osmond, C., Barker, D. J. & Eriksson, J. G. Association of schizophrenia with low maternal body mass index, small size at birth, and thinness during childhood. Arch. Gen. Psychiatry 58, 48–52 (2001).

  37. 37.

    Weiser, M. et al. Body mass index and future schizophrenia in Israeli male adolescents. J. Clin. Psychiatry 65, 1546–1549 (2004).

  38. 38.

    Sanders, R., Keshavan, M. & Schooler, N. Neurological examination abnormalities in neuroleptic-naive patients with first-break schizophrenia: preliminary results. Am. J. Psychiatry 151, 1231–1233 (1994).

  39. 39.

    Gupta, S. et al. Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. Am. J. Psychiatry 152, 191–196 (1995).

  40. 40.

    Peralta, V. et al. Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders. Psychol. Med. 41, 1279–1289 (2011).

  41. 41.

    Green, M. F. & Leitman, D. I. Social cognition in schizophrenia. Schizophr. Bull. 34, 670–672 (2008).

  42. 42.

    Firth, J. et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr. Bull; doi: 10.1093/schbul/sbw115 (2016).

  43. 43.

    van Praag, H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25, 8680–8685 (2005).

  44. 44.

    Eriksson, P. S. et al. Neurogenesis in the adult human hippocampus. Nat. Med. 4, 1313–1317 (1998).

  45. 45.

    Ernst, A. et al. Neurogenesis in the striatum of the adult human brain. Cell 156, 1072–1083 (2014).

  46. 46.

    Inta, D., Lang, U. E., Borgwardt, S., Meyer-Lindenberg, A. & Gass, P. Adult neurogenesis in the human striatum: possible implications for psychiatric disorders. Mol. Psychiatry 21, 446–447 (2016).

  47. 47.

    Mäkikyrö, T. et al. Accuracy of register-based schizophrenia diagnoses in a genetic study. Eur. Psychiatry 13, 57–62 (1998).

  48. 48.

    Suvisaari, J. M., Haukka, J. K., Tanskanen, A. J. & Lönnqvist, J. K. Decline in the incidence of schizophrenia in Finnish cohorts born from 1954 to 1965. Arch. Gen. Psychiatry 56, 733–740 (1999).

  49. 49.

    Mansikkaniemi, K. et al. Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults: the cardiovascular risk in young Finns study. Ann. Med. 44, 733–744 (2012).

  50. 50.

    Tudor-Locke, C., Williams, J., Reis, J. & Pluto, D. Utility of pedometers for assessing physical activity: construct validity. Sports Med. 34, 281–291 (2004).

  51. 51.

    Telama, R. et al. Physical activity from childhood to adulthood: a 21-year tracking study. Am. J. Prev. Med. 28, 267–273 (2005).

  52. 52.

    Raitakari, O. T. et al. Cohort profile: the cardiovascular risk in young Finns study. Int. J. Epidemiol. 37, 1220–1226 (2008).

  53. 53.

    Telama, R., Leskinen, E. & Yang, X. Stability of habitual physical activity and sport participation: a longitudinal tracking study. Scand. J. Med. Sci. Sports 6, 371–378 (1996).

  54. 54.

    Cole, T. J., Flegal, K. M., Nicholls, D. & Jackson, A. A. Body mass index cut offs to define thinness in children and adolescents: international survey. Br. Med. J. 335, 1–8 (2007).

  55. 55.

    Cole, T. J., Bellizzi, M. C., Flegal, K. M. & Dietz, W. H. Establishing a standard definition for child overweight and obesity worldwide: international survey. Br. Med. J. 320, 1240–1243 (2000).

  56. 56.

    Zou, G. A modified poisson regression approach to prospective studies with binary data. Am. J. Epidemiol. 159, 702–706 (2004).

  57. 57.

    Zou, G. Y. & Donner, A. Extension of the modified poisson regression model to prospective studies with correlated binary data. Stat. Methods Med. Res. 22, 661–670 (2011).

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We would like to thank Ville Aalto and Irina Lisinen for data management, the participants in the YFS study and YFS study researchers. The Young Finns Study has been financially supported by the Academy of Finland: grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117797 (Gendi), and 41071 (Skidi), the Social Insurance Institution of Finland, Kuopio, Tampere and Turku University Hospital Medical Funds, Juho Vainio Foundation, Sigrid Juselius Foundation, Yrjö Jahnsson Foundation, Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation, and Emil Aaltonen Foundation.

Author contributions

J.H. and O.R. had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. J.H., R.K.R.S., J.V., and O.R. were responsible for the study design. T.T., R.T., N.H.K. were responsible for the physical activity/exercise data. E.S. drafted the first version of the manuscript and did the analyses. M.M.S. was responsible for the statistical methods. All authors critically revised the manuscript for important intellectual content. All authors approved the final version for publication.

Competing interests

The authors report no biomedical financial interests or potential conflicts of interest.

Author information


  1. Department of Psychiatry, University of Turku, Turku, Finland

    • Elina Sormunen
    • Raimo K. R. Salokangas
    •  & Jarmo Hietala
  2. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

    • Maiju M. Saarinen
    •  & Olli Raitakari
  3. LIKES—Research Center for Sport and Health Sciences, Jyväskylä, Finland

    • Risto Telama
    •  & Tuija Tammelin
  4. Department of Pediatrics, University of Tampere and Tampere University Hospital, Tampere, Finland

    • Nina Hutri-Kähönen
  5. Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland

    • Jorma Viikari
  6. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

    • Olli Raitakari
  7. General Hospital Psychiatry Unit, Turku University Hospital, Turku, Finland

    • Jarmo Hietala
  8. Turku Psychiatry, Turku, Finland

    • Jarmo Hietala


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Corresponding author

Correspondence to Jarmo Hietala.

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