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Testosterone replacement therapy is associated with high satisfaction rates: results of a survey study

International Journal of Impotence Research (2023)Cite this article

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Abstract

Despite a well-documented increase in both the prevalence of Testosterone Deficiency (TD) and prescription of testosterone replacement therapy (TRT), few studies have investigated the preferences of patients receiving TRT and factors associated with increased treatment satisfaction. To investigate the preferences of patients receiving TRT and factors associated with improved treatment satisfaction, an open survey was completed by 140 men receiving TRT at a single institution. Survey questions investigated demographics, symptom burden of TD, TRT regimen, treatment preferences, and treatment satisfaction. 62.7% of patients were satisfied with their current TRT regimen. Those using auto-injectors (91.7%, odds ration [OR] = 9.3), subcutaneous pellets (90.0%, OR = 15.2), and intramuscular injections (67.5%, OR = 5.7), were with significantly increased satisfaction rates (p < 0.05). The majority of patients indicated that they would prefer to receive TRT injections when self-administered or administered at home. While patients noted that treatment efficacy was a significant driving factor when evaluating a TRT regimen, few patients felt that cost was the most significant factor.

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Fig. 1: ADAM and SHIM questionnaire scores by regimen.
Fig. 2: Desired benefits of TRT.
Fig. 3: Side effects of TRT for which participants are concerned.

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Additional data are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Urology, University of California, Irvine, CA, USA

    Charles Loeb, Jake A. Miller, Douglas Schneider, Logan Grimaud, Muhammed A. Moukhtar Hammad & Faysal A. Yafi

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Contributions

The following authors were involved in the conception of the study (CL and FY), data collection (CL, JM, DS, LG, and MHM), data analysis and interpretation (JM and MHM), manuscript drafting (JM), manuscript revising (CL, JM, DS, LG, MHM, and FY), and approval of the final manuscript (CL, JM, DS, LG, MHM, and FY).

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Correspondence to Jake A. Miller.

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Competing interests

FAY work has received funding from Viome. He has additionally received compensation as a member of the advisory board of Coloplast, Sprout, Cynosure, and Promescent, and has served as a speaker for Antares Pharma and Clarus Therapeutics. The remaining authors declare no competing interests.

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Loeb, C., Miller, J.A., Schneider, D. et al. Testosterone replacement therapy is associated with high satisfaction rates: results of a survey study. Int J Impot Res (2023). https://doi.org/10.1038/s41443-023-00724-2

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