Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Comment
  • Published:

Hydrogen inhalation therapy for inflammation and eye diseases: a review of the literature

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Liang IC, Ko WC, Hsu YJ, Lin YR, Chang YH, Zong XH, et al. The anti-inflammatory effect of hydrogen gas inhalation and its influence on laser-induced choroidal neovascularization in a mouse model of neovascular age-related macular degeneration. Int J Mol Sci. 2021;22:12049. https://doi.org/10.3390/ijms222112049.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Li SY, Xue RY, Wu H, Pu N, Wei D, Zhao N, et al. Novel role of molecular hydrogen: the end of ophthalmic diseases? Pharmaceuticals. 2023;16:1567. https://doi.org/10.3390/ph16111567.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Otsuka M, Arai K, Yoshida T, Hayashi A. Correction: Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration hydrogen gas. Graefes Arch Clin Exp Ophthalmol. 2023. https://doi.org/10.1007/s00417-023-06340-6.

  4. Artamonov MY, Martusevich AK, Pyatakovich FA, Minenko IA, Dlin SV, LeBaron TW. Molecular hydrogen: from molecular effects to stem cells management and tissue regener''ation. Antioxidants. 2023;12:636. https://doi.org/10.3390/antiox12030636.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Johnsen HM, Hiorth M, Klaveness J. Molecular hydrogen therapy-a review on clinical studies and outcomes. Molecules. 2023;28:7785. https://doi.org/10.3390/molecules28237785.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cheng D, Long J, Zhao L, Liu J. Hydrogen: a rising star in gas medicine as a mitochondria-targeting nutrient via activating keap1-Nrf2 antioxidant system. Antioxidants. 2023;12:2062. https://doi.org/10.3390/antiox12122062.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Cejka C, Kubinova S, Cejkova J. The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved. Free Radic Res. 2019;53:237–47. https://doi.org/10.1080/10715762.2019.1582770.

    Article  CAS  PubMed  Google Scholar 

  8. Zhang ZQ, Xie Z, Chen SY, Zhang X. Mitochondrial dysfunction in glaucomatous degeneration. Int J Ophthalmol. 2023;16:811–23. https://doi.org/10.18240/ijo.2023.05.20.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Perveen I, Bukhari B, Najeeb M, Nazir S, Faridi TA, Farooq M, et al. Hydrogen therapy and its future prospects for ameliorating COVID-19: clinical applications, efficacy, and modality. Biomedicines. 2023;11:1892. https://doi.org/10.3390/biomedicines11071892.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yoshiyasu Takefuji.

Ethics declarations

Competing interests

The author declares no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Takefuji, Y. Hydrogen inhalation therapy for inflammation and eye diseases: a review of the literature. Eye (2024). https://doi.org/10.1038/s41433-024-03083-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1038/s41433-024-03083-4

Search

Quick links