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Nutrition during the early life cycle

Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?

European Journal of Clinical Nutrition volume 76, pages 1705–1712 (2022)Cite this article

Subjects

Abstract

Intrauterine environment can influence the offspring’s body adiposity whose distribution affect the cardiometabolic risk. Underlying mechanisms may involve the gut microbiome. We investigated associations of gestational weight gain with the adult offspring’s gut microbiota, body adiposity and related parameters in participants of the Nutritionists’ Health Study.

Methods

This cross-sectional analysis included 114 women who had early life and clinical data, body composition, and biological samples collected. The structure of fecal microbiota was analyzed targeting the V4 region of the 16 S rRNA gene. Beta diversity was calculated by PCoA and PERMANOVA used to test the impact of categorical variables into the diversity. Bacterial clusters were identified based on the Jensen-Shannon divergence matrix and Calinski–Harabasz index. Correlations were tested by Spearman coefficient.

Results

Median age was 28 (IQR 24–31) years and BMI 24.5 (IQR 21.4–28.0) kg/m2. Fifty-eight participants were assigned to a profile driven by Prevotella and 56 to another driven by Blautia. Visceral adipose tissue was correlated to abundance of Acidaminococcus genus considering the entire sample (r = 0.37; p < 0.001) and the profiles (Blautia: r = 0.35, p = 0.009, and Prevotella: r = 0.38, p = 0.006). In Blautia-driven profile, the same genus was also correlated to maternal gestational weight gain (r = 0.38, p = 0.006).

Conclusions

Association of Acidaminococcus with gestational weight gain could reinforce the relevance with mothers’ nutritional status for gut colonization at the beginning of life. Whether Acidaminococcus abundance could be a marker for central distribution of adiposity in young women requires further investigation.

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Fig. 1: Six most abundant phyla in the NutriHS sample studied.
Fig. 2: Bacterial clusters identified in the NutriHS participants.

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Data availability

The data that support the results of our study are openly available in Europeia Nucleotide Archive at https://www.ebi.ac.uk/ena/browser/home, with the reference number PRJEB49536. We confirm that the findings from our analyses are available within the article.

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Acknowledgements

We thank the Clinical Pathology Laboratory of UNICAMP Hospital and the Growth and Body Composition Laboratory of UNICAMP Center for Investigation in Pediatrics. We also thank Vinícius Santos for helping with clinical examinations.

Funding

This work was supported by Foundation for Research Support of the State of São Paulo – FAPESP (grant 2018/11433–9. 2018/11401–0).

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Authors and Affiliations

  1. Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil

    R G B O N Freitas & S R G Ferreira

  2. Laboratory of Investigation in Metabolism and Diabetes, Gastrocentro, School of Medical Sciences - University of Campinas, São Paulo, Brazil

    R G B O N Freitas, A C J Vasques, F B Ribeiro, I Solar & B Geloneze

  3. School of Applied Sciences - University of Campinas, São Paulo, Brazil

    A C J Vasques, I Solar & M G Barbosa

  4. Oswaldo Cruz Foundation, Belo Horizonte, São Paulo, Brazil

    G R Fernandes

  5. Department of Preventive Medicine, Federal University of São Paulo, São Paulo, Brazil

    B Almeida-Pititto

  6. Obesity and Comorbidities Research Center, University of Campinas, São Paulo, Brazil

    B Geloneze

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Contributions

RGBONF, ACJV, GRF, BAP, SRGF contributed to conception and design. RGBONF; ACJV; GRF; FFB; IS; MGB; BG; SRGF contributed to acquisition, analysis, or interpretation. RGBONF; SRGF drafted the manuscript. RGBONF; ACJV; GRF; BG; SRGF critically revised the manuscript. RGBONF; ACJV; GRF; FFB; IS; MGB; BAP; BG; SRGF gave final approval agrees to be accountable for all aspects of work ensuring integrity and accuracy.

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Correspondence to S R G Ferreira.

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Freitas, R.G.B.O.N., Vasques, A.C.J., Fernandes, G.R. et al. Gestational weight gain and visceral adiposity in adult offspring: Is there a link with the fecal abundance of Acidaminococcus genus?. Eur J Clin Nutr 76, 1705–1712 (2022). https://doi.org/10.1038/s41430-022-01182-7

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