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Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed

The Journal of Antibiotics volume 74, pages 105–110 (2021)Cite this article

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Abstract

A new lipopeptide, pseudoalteropeptide A (1) was isolated from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4. The structure was elucidated by spectroscopic analyses including NMR and MSMS spectra. It showed moderate iron chelating activity as well as cytotoxic activity against Jurkat human T lymphocyte cells. isolation/marine bacterium/natural product/structure elucidation

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Acknowledgements

This work was supported in part by Japan Agency for Medical Research and Development (AMED) under Grant Number JP19ae0101045 for KS, and JSPS KAKENHI Grant Number 19K23671 for RU.

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Authors and Affiliations

  1. National Institute of Advanced Industrial Science and Technology, 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan

    Reiko Ueoka, Noritaka Kagaya, Hikaru Suenaga & Kazuo Shin-ya

  2. Center of Molecular Biosciences, Tropical Biosphere Research Center, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 902-0213, Japan

    Naoya Shinzato

  3. Biotechnology Research Center, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan

    Kazuo Shin-ya

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  1. Reiko Ueoka
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  2. Naoya Shinzato
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  5. Kazuo Shin-ya
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Correspondence to Kazuo Shin-ya.

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Ueoka, R., Shinzato, N., Kagaya, N. et al. Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed. J Antibiot 74, 105–110 (2021). https://doi.org/10.1038/s41429-020-00377-z

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