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Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201

The Journal of Antibiotics volume 74, pages 190–198 (2021)Cite this article

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Abstract

Four undescribed polyketide derivatives, named arthproliferins A–D (1–4), and one undescribed phenylspirodrimane derivative, named arthproliferin E (7), along with 11 known metabolites (5, 6, 8–16) were isolated from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. Their structures were determined through spectroscopic methods, X-ray crystallography, and ECD analysis. Compounds 1 and 3–15 were evaluated for their cytotoxic, and antibacterial activities. Among them, compounds 1 and 15 displayed moderate inhibitory activity against methicillin-resistant Staphylococcus aureus ATCC 29213 with an MIC value of 78 and 39 µg/mL, respectively. Furthermore, compound 15 displayed strong cytotoxic activities against the tested cell line with IC50 values less than 39 nM.

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Acknowledgements

This study was supported by grants from the National Natural Science Foundation of China (21977102, 81860626, 81973235, and 21772210), Guangzhou Science and Technology Project (201804010462), the Natural Science Foundation of Guangdong Province (2018A0303130219), Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province (GDOE[2019]A28), National Major Scientific and Technological Special Project for Significant New Drugs Development (2018ZX09735001-002-003), Project from Institution of South China Sea Ecology and Environmental Engineering, CAS (ISEE2018PY04). We are grateful to Dr Z. Xiao, A. Sun, C. Li, and Y. Zhang in the analytical facilities at SCSIO for recording spectroscopic data.

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Authors and Affiliations

  1. Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, CAS, Guangzhou, 510301, China

    Bin Yang, Jieyi Long, Xiaoyan Pang, Xiuping Lin, Shengrong Liao, Junfeng Wang, Xuefeng Zhou & Yonghong Liu

  2. Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China

    Bin Yang, Jieyi Long, Xiaoyan Pang, Xiuping Lin, Shengrong Liao, Junfeng Wang, Xuefeng Zhou & Yonghong Liu

  3. College of Pharmacy, Guilin Medical University, Guilin, 541004, PR China

    Yunqiu Li

  4. University of Chinese Academy of Sciences, Beijing, 100049, China

    Yonghong Liu

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  1. Bin Yang
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41429_2020_386_MOESM1_ESM.doc

Structurally Diverse Polyketides and Phenylspirodrimanes from the Soft Coral-associated Fungus Stachybotrys chartarum SCSIO41201

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Yang, B., Long, J., Pang, X. et al. Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. J Antibiot 74, 190–198 (2021). https://doi.org/10.1038/s41429-020-00386-y

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