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Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response

Polymer Journal volume 54, pages 1237–1252 (2022)Cite this article

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Abstract

Piezoelectric poly-L-lactide (PLLA) is a biodegradable polymer used in various biomedical applications. However, tailoring and controlling the structure of PLLA to enhance its piezoelectric response remains a challenge. In this work, extensive characterization was performed to reveal the effect of the reduced graphene oxide (rGO) content (0.2, 0.7, and 1.0 wt%) on the morphology, structure, thermal and piezoelectric behavior of PLLA scaffolds. Randomly oriented homogeneous fibers and a quasi-amorphous structure for pure PLLA and hybrid PLLA-rGO scaffolds were revealed. The addition of rGO affected the molecular structure of the PLLA scaffolds: for example, the number of polar C=O functional groups was increased. Increasing the content of rGO to 1 wt% resulted in decreased glass transition and melting temperatures and increased the degree of crystallinity of the scaffolds. The addition of 0.2 wt% rGO enhanced the effective local vertical and lateral piezoresponses by 2.3 and 15.4 times, respectively, in comparison with pure PLLA fibers. The presence of the shear piezoelectric α-phase (P212121) in uniaxially oriented PLLA fibers and C=O bond rotation in the polymer chains explained the observed piezoresponse. Thus, this study revealed routes to prepare hybrid biodegradable scaffolds with enhanced piezoresponse for tissue engineering applications.

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Acknowledgements

The authors acknowledge the results obtained and their discussion in cooperation with A.M.S. Jekhan (TPU). The research was carried out at Tomsk Polytechnic University within the framework of the Tomsk Polytechnic University Development Program. The authors are thankful to the Central Laboratories of TPU (Analytical Center) for the XPS measurements. Work was conducted with the application of equipment of the Tomsk Regional Core Shared Research Facilities Centre of National Research Tomsk State University. The financial support (PFM study) from the Ministry of Science and Higher Education (grant agreement #075-15-2021-588 from 1.06.2021) and Russian Science Foundation (project # 22-13-20043, materials purchase, SEM and DSC analyses) is acknowledged. The work was also supported by the Special Research Fund (BOF) of Ghent University [grant numbers BOF16/FJD/029 (RVC and AGS)] and the German-Russian Interdisciplinary Science Center (G-RISC) (project number M-2021 a-8_d). The authors strongly condemn all violence and promote peaceful solutions.

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Authors and Affiliations

  1. Physical Materials Science and Composite Materials Centre, National Research Tomsk Polytechnic University, 634050, Tomsk, Russia

    Igor O. Pariy, Roman V. Chernozem, Polina V. Chernozem, Yulia R. Mukhortova, Maria A. Surmeneva & Roman A. Surmenev

  2. Piezo- and Magnetoelectric Materials Research & Development Centre, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050, Tomsk, Russia

    Roman V. Chernozem, Maria A. Surmeneva & Roman A. Surmenev

  3. Department of Biotechnology, Ghent University, 9000, Ghent, Belgium

    Roman V. Chernozem & Andre G. Skirtach

  4. Institute for Materials Science and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, 45141, Essen, Germany

    Vladimir V. Shvartsman & Doru C. Lupascu

  5. Institute of Inorganic Chemistry, University of Cologne, Greinstr. 6, 50939, Cologne, Germany

    Sanjay Mathur & Roman A. Surmenev

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  1. Igor O. Pariy
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Contributions

IOP: Investigation, Visualization, Writing—original draft. RVC: Conceptualization, Investigation, Writing—review & editing. PVC: Formal analysis, Visualization. YRM: Investigation. AGS: Conceptualization, Resources. VVS: Supervision, Conceptualization, Resources. DCL: Supervision, Resources. MAS: Conceptualization, Investigation. RAS: Supervision, Conceptualization, Resources, Project management, Writing—review & editing.

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Correspondence to Roman A. Surmenev.

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Pariy, I.O., Chernozem, R.V., Chernozem, P.V. et al. Hybrid biodegradable electrospun scaffolds based on poly(l-lactic acid) and reduced graphene oxide with improved piezoelectric response. Polym J 54, 1237–1252 (2022). https://doi.org/10.1038/s41428-022-00669-1

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