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The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection

Cellular & Molecular Immunology volume 18, pages 498–500 (2021)Cite this article

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Invasive fungal diseases (IFD) impact morbidity, mortality, hospital stay and healthcare costs in critically ill patients, constituting an unmet medical need.1 Pathogenic fungi rarely cause IFD in immunocompetent individuals but become life-threatening in cases of immunodeficiency, young infants, disrupted mucosal barriers or polyantibiotic therapy, highlighting the role of immune surveillance in IFD control.2

Host fungal recognition relies on pattern recognition receptors (PRRs) mainly expressed by innate immune cells to induce protective responses. PRRs from different structural families, such as Toll-like receptors (TLRs), C-type lectin receptors (CLR), scavenger receptors (SRs), nucleotide-binding and oligomerization domain-like receptors (NLR), and retinoid acid-inducible gene-like receptors (RLR) target conserved structural components of fungal cells (e.g., mannans, β-glucans, or chitins)—collectively designated microbial-associated molecular patterns (MAMPs).2 The identification of genetic variants in patients and the development of knockout mouse models have paved road to the discovery of PRR mechanisms in antifungal immunity and novel immunomodulatory strategies against IFD.2

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Acknowledgements

We thank Marcos Isamat for critically reviewing the paper and Joaquin García-Luna for excellent technical assistance. This work was supported by the Spanish Ministerio de Economía y Competitividad (SAF-2016-80535-R), co-financed by the European Development Regional Fund “A way to achieve Europe” to F.L. M.V.-d-A., C.C., S.C.-L., I.S., and E.C. are recipients of fellowships from the Ministerio de Economía y Competitividad (BES-2014-069237; BES-2017-082107), the Ministerio de Educación Cultura y Deporte (FPU15/02897), the Fundação para a Ciência e a Tecnologia (SFRH/BD/75738/2011), and the European Community Seventh Framework Program (BIOTRACK, FP7/2007/2013; 229673).

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Authors and Affiliations

  1. Immunoreceptors of the Innate and Adaptive System, Institut d’Investigacions Biomèdiques August Pi i Sunyer, 08036, Barcelona, Spain

    María Velasco-de-Andrés, Cristina Català, Sergi Casadó-Llombart, Inês Simões, Esther Carreras & Francisco Lozano

  2. Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, 28220, Majadahonda, Spain

    Oscar Zaragoza

  3. Servei d’Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic de Barcelona, 08036, Barcelona, Spain

    Francisco Lozano

  4. Departament de Biomedicina, Universitat de Barcelona, 08036, Barcelona, Spain

    Francisco Lozano

Authors
  1. María Velasco-de-Andrés
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Contributions

M.V.-d-A., C.C., I.S., S.C.-L., and E.C. performed the experiments. M.V.-d-A. and F.L. wrote the paper. E.C., O.Z., and F.L. designed and supervised the project. All authors discussed the results and participated in revising the paper.

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Correspondence to Francisco Lozano.

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The authors declare no competing interests.

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Velasco-de-Andrés, M., Català, C., Casadó-Llombart, S. et al. The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection. Cell Mol Immunol 18, 498–500 (2021). https://doi.org/10.1038/s41423-020-0434-7

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