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Post-transplant cyclophosphamide with Sirolimus or Cyclosporine for GvHD prophylaxis in matched related and unrelated transplantation: a two-center analysis on 213 consecutive patients

Bone Marrow Transplantation (2024)Cite this article

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Allogeneic hematopoietic stem cell transplantation (allo-SCT) is a potentially curative option for patients with hematological malignancies but graft-versus-host disease (GvHD) is still a major cause of morbidity and mortality even in the setting of HLA-matched donors [1]. The ideal GvHD prophylaxis to choose remains to be identified.

The most widely used strategy for GvHD prevention, at least in Europe, is the addition of antithymocyte or antilymphocyte globulin (ATG/ALG) to the standard prophylaxis with a calcineurin inhibitor and either methotrexate or mycophenolate mofetil (MMF) [2, 3], both for matched unrelated and related donors (MUD and MRD), as detailed in the consensus recommendations of the European Society for Blood and Marrow Transplantation [4].

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Data availability

The dataset supporting the conclusions of this article are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank the hematology teams of Fondazione Policlinico Gemelli and of Ospedale San Raffaele for their help in the care of these patients and the Italian Ministry of Health – Ricerca Corrente. The authors declare that no source of funding was used for the present research.

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Authors and Affiliations

  1. Hematology and Bone Marrow transplant Unit, San Raffaele Scientific Institute IRCCS, Milano, Italy

    Simona Piemontese, Maria Teresa Lupo Stanghellini, Jacopo Peccatori, Magda Marcatti, Raffaella Greco, Alessandro Bruno & Fabio Ciceri

  2. Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

    Federica Sora, Simona Sica, Elisabetta Metafuni, Sabrina Giammarco, Andrea Bacigalupo & Patrizia Chiusolo

  3. Università Cattolica del Sacro Cuore, Roma, Italy

    Federica Sora, Simona Sica, Andrea Bacigalupo & Patrizia Chiusolo

  4. Vita-Salute San Raffaele University, Milano, Italy

    Fabio Ciceri

Authors
  1. Simona Piemontese
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  2. Maria Teresa Lupo Stanghellini
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  13. Patrizia Chiusolo
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Contributions

All authors contributed to patients clinical care and data collection. SP, MTLS, FC, AB and PC designed the study. SP performed statistical analysis and prepared the figures and tables. SP, MTLS, FC, AB and PC wrote the paper. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Simona Piemontese.

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The authors declare no competing interests.

Ethics approval and consent to participate

Each center’s institutional review boards approved treatment protocols according to the Declaration of Helsinki.

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Piemontese, S., Lupo Stanghellini, M.T., Sora, F. et al. Post-transplant cyclophosphamide with Sirolimus or Cyclosporine for GvHD prophylaxis in matched related and unrelated transplantation: a two-center analysis on 213 consecutive patients. Bone Marrow Transplant (2024). https://doi.org/10.1038/s41409-024-02221-6

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  • DOI: https://doi.org/10.1038/s41409-024-02221-6

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