Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Hematopoietic stem cell transplantation using non-cryopreserved peripheral blood stem cells graft is effective in multiple myeloma and lymphoma

Bone Marrow Transplantation volume 53, pages 1198–1200 (2018)Cite this article

Subjects

Cryopreservation of hematopoietic stem cells (HSCs) has been a standard of care at many centers. It is technically demanding, expensive and limits the ability of many hematology centers to perform such procedures in resource constrained scenario. Recently, Journal has published two articles that question the long-standing practice of cryopreservation of HSCs. Kardduss-Urueta et al. [1] in a large multicenter trial showed that cryopreservation of HSCs is not required. They also did not find any correlation between numbers of storage days at 4 °C and viability after storage or rates of recovery of neutrophils or platelets. Another study has in fact demonstrated that non-cryopreserved stem cells are superior to cryopreserved stem cells with faster engraftment, lower incidence of febrile neutropenia and shorter hospital stay after the transplantation procedure [2].

Hematopoietic stem cells remain viable for several days at 4 °C storage [3, 4]. Studies with non-cryopreserved HSCs are limited [1, 2, 5,6,7,8]. In support of these, we report the outcome of ASCT in MM and lymphoma with mobilized non-cryopreserved peripheral blood stem cell (PBSC) graft in 76 patients in terms of feasibility, safety, and efficacy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kardduss-Urueta A, Gale RP, Gutierrez-Aguirre CH, Herrera-Rojas MA, Murrieta-Álvarez I, Perez-Fontalvo R et al. Freezing the graft is not necessary for autotransplants for plasma cell myeloma and lymphomas. Bone Marrow Transplant. 2018. https://doi.org/10.1038/s41409-017-0047-7.

    Article  CAS  Google Scholar 

  2. Sarmiento M, Ramírez P, Parody R, Salas MQ, Beffermann N, Jara V et al. Advantages of non-cryopreserved autologous hematopoietic stem cell transplantation against a cryopreserved strategy. Bone Marrow Transplant. 2018. https://doi.org/10.1038/s41409-018-0117-5.

    Article  CAS  Google Scholar 

  3. Wannesson L, Panzarella T, Mikhael J, Keating A. Feasibility and safety of autotransplants with noncryopreserved marrow or peripheral blood stem cells: a systematic review. Ann Oncol. 2007;18:623–32.

    Article  CAS  Google Scholar 

  4. Hechler G, Weide R, Heymanns J, Köppler H, Havemann K. Storage of non cryopreserved peripheral blood stem cells for transplantation. Ann Hematol. 1996;72:303–6.

    Article  CAS  Google Scholar 

  5. López-Otero A, Ruiz-Delgado GJ, Ruiz-Argüelles GJ. A simplified method for stem cell autografting in multiple myeloma: a single institution experience. Bone Marrow Transplant. 2009;44:715–9.

    Article  Google Scholar 

  6. Bekadja MA, Brahimi M, Osmani S, Arabi A, Bouhass R, Yafour N. A simplified method for autologous stem cell transplantation in multiple myeloma. Hematol Oncol Stem Cell Ther. 2012;5:49–53.

    Article  CAS  Google Scholar 

  7. Ramzi M, Zakerinia M, Nourani H, Dehghani M, Vojdani R, Haghighinejad H. Non-cryopreserved hematopoietic stem cell transplantation in multiple myeloma, a single center experience. Clin Transplant. 2012;26:117–22.

    Article  Google Scholar 

  8. Kayal S, Sharma A, Iqbal S, Tejomurtula T, Cyriac SL, Raina V. High dose chemotherapy and autologous stem cell transplantation in multiple myeloma: a single institution experience at All India Institute of Medical Sciences, New Delhi, using non cryopreserved peripheral blood stem cells. Clin Lymphoma Myeloma Leuk. 2014;14:140–7.

    Article  Google Scholar 

  9. Naithani R, Dayal N, Dixit G. Single versus dual platform analysis for hematopoietic stem cell enumeration using ISHAGE protocol. Indian J Hematol Blood Transfus. 2017;33:370–4.

    Article  Google Scholar 

  10. Shaw PJ, Nath CE, Lazarus HM. Not too little, not too much-just right! (Better ways to give high dose melphalan). Bone Marrow Transplant. 2014;49:1457–65.

    Article  CAS  Google Scholar 

  11. Giralt S, Costa L, Schriber J, Dipersio J, Maziarz R, McCarty J, et al. Optimizing autologous stem cell mobilization strategies to improve patient outcomes: consensus guidelines and recommendations. Biol Blood Marrow Transplant. 2014;20:295–308.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology & Bone Marrow Transplantation, Max Superspeciality Hospital, New Delhi, India

    Rahul Naithani

  2. Department of Lab Medicines, Max Superspeciality Hospital, New Delhi, India

    Nitin Dayal

  3. Department of Transfusion Medicine, Max Superspeciality Hospital, New Delhi, India

    Sangeeta Pathak & Reeta Rai

Authors
  1. Rahul Naithani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nitin Dayal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sangeeta Pathak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Reeta Rai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rahul Naithani.

Ethics declarations

Informed consent statement

Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Institutional review board statement: This study was reviewed and approved by the scientific Committee of Max Hospital.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Naithani, R., Dayal, N., Pathak, S. et al. Hematopoietic stem cell transplantation using non-cryopreserved peripheral blood stem cells graft is effective in multiple myeloma and lymphoma. Bone Marrow Transplant 53, 1198–1200 (2018). https://doi.org/10.1038/s41409-018-0174-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-018-0174-9

Search

Advanced search

Quick links