Abstract
Introduction: Vitamin D requirement concept was changed in recent years, pregnancy and intra uterine life is a crucial period of life for development and we do not know exact amount of vitamin requirement in that. This study is a randomized trial to find doses of vitamin D in pregnancy to make sufficient level in newborn.
Material and method: In 2009 at Yazd in center of Iran on 52 healthy pregnant women this study was performed, they randomly received 50,000 or 100,000 IU vitamin D3/month from second trimester and 17 others treated first as deficiency with 200,000 IU vitamin D3 then 50,000IU/month. 25-OH vitamin D in cord blood was check by chemiluminescence immunoassay and level more than 20ng/ml accepted as sufficient.
Result: All mothers had vitamin level below 30 ng/ml at first trimester, 24 % of mothers on 50,000/month(about2000IU/day ) could not achieve sufficient level in newborns. All in other two group had level more than 20ng.ml in their babies. we could not find any side effect during consumption.
Conclusion: In area with high prevalence of vitamin D deficiency in mothers about 4000IU /day vitamin D3 from second trimester of pregnancy is needed to make level more than 20ng/ml of 25-OH vitamin D in newborn, consuming less than 2000IU /day is not sufficient in all.
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Shakiba, M. Vitamin D Requirement in Pregnancy to Maintain Sufficient Vitamin in Newborn a Randomized Trial. Pediatr Res 70 (Suppl 5), 831 (2011). https://doi.org/10.1038/pr.2011.1056
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DOI: https://doi.org/10.1038/pr.2011.1056