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Rewiring cell polarity signaling in cancer

Oncogene volume 34, pages 939–950 (2015)Cite this article

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Abstract

Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble polarity complexes function to specify and maintain apical and basolateral membrane domains, which are essential to organize intracellular signaling pathways that maintain epithelial homeostasis. Disruption of apical–basal polarity proteins facilitates rewiring of oncogene and tumor suppressor signaling pathways to deregulate proliferation, apoptosis, invasion and metastasis. Moreover, apical–basal polarity integrates intracellular signaling with the microenvironment by regulating metabolic signaling, extracellular matrix remodeling and tissue level organization. In this review, we discuss recent advances in our understanding of how polarity proteins regulate diverse signaling pathways throughout cancer progression from initiation to metastasis.

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Acknowledgements

Research by LM is supported by grants from the Terry Fox Research Institute (1009) and Canadian Institutes of Health Research (MOP-119482). LM is an FRQS Research Scholar. RH is supported by the McGill Integrated Cancer Research Training Program and a Canderel Studentship award.

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  1. Department of Oncology, Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

    R Halaoui & L McCaffrey

  2. Division of Experimental Medicine, McGill University, Montreal, QC, Canada,

    R Halaoui & L McCaffrey

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Halaoui, R., McCaffrey, L. Rewiring cell polarity signaling in cancer. Oncogene 34, 939–950 (2015). https://doi.org/10.1038/onc.2014.59

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