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The polarity protein PARD3 and cancer

Oncogene volume 40, pages 4245–4262 (2021)Cite this article

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Abstract

Tissue disorganisation is one of the main hallmarks of cancer. Polarity proteins are responsible for the arrangement of cells within epithelial tissues through the asymmetric organisation of cellular components. Partition defective 3 (PARD3) is a master regulator of the Par polarity complex primarily due to its ability to form large complexes via its self-homologous binding domain. In addition to its role in polarity, PARD3 is a scaffolding protein that binds to intracellular signalling molecules, many of which are frequently deregulated in cancer. The role of PARD3 has been implicated in multiple solid cancers as either a tumour suppressor or promoter. This dual functionality is both physiologically and cell context dependent. In this review, we will discuss PARD3’s role in tumourigenesis in both laboratory and clinical settings. We will also review several of the mechanisms underpinning PARD3’s function including its association with intracellular signalling pathways and its role in the regulation of asymmetric cell division.

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Fig. 1: Schematic of mammalian PARD3 isoforms.
Fig. 2: Schematic representation of PARD3 binding partners.
Fig. 3: Schematic representation of the role of PARD3 in different intracellular signalling pathways.

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  1. These authors contributed equally: Farzaneh Atashrazm, Sarah Ellis

Authors and Affiliations

  1. Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia

    Farzaneh Atashrazm

  2. Olivia Newton-John Cancer Research Institute, and School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, VIC, Australia

    Sarah Ellis

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Atashrazm, F., Ellis, S. The polarity protein PARD3 and cancer. Oncogene 40, 4245–4262 (2021). https://doi.org/10.1038/s41388-021-01813-6

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