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PAG - a multipurpose transmembrane adaptor protein

Oncogene volume 33, pages 4881–4892 (2014)Cite this article

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Abstract

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), also known as Csk-binding protein (Cbp), is a ubiquitously expressed transmembrane adaptor protein present in lipid rafts and involved in a number of signaling pathways. It helps recruit cytoplasmic C-terminal Src kinase (Csk) to lipid raft-associated Src kinases, mediates a link to actin cytoskeleton and interacts with several other important cytoplasmic and plasma membrane-associated proteins. In recent years, PAG has been implicated in various aspects of cancer cell biology. Our review covers all so far published data on this interesting protein.

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Abbreviations

ALL:

acute lymphoblastic leukemia 

BCR:

B-cell receptor

Cbp:

Csk-binding protein

DRM:

detergent-resistant membrane microdomain

Epo:

erythropoietin

NSCLC:

non-small cell lung cancer

PAG:

phosphoprotein associated with glycosphingolipid-enriched microdomains

PTP:

protein tyrosine phosphatase

RCC:

renal cell carcinomas

SH2, SH3:

Src homology domain

SFK:

Src family kinase

TCR:

T-cell receptor

TRAP:

transmembrane adaptor protein

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Acknowledgements

This work was supported by Grant No. P302-12-G101 from the Czech Science Foundation and by the Institute of Molecular Genetics ASCR (RVO 68378050).

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  1. M Hrdinka

    Present address: 2Current address: Leibniz Institute for Neurobiology, Magdeburg, Germany.,

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  1. Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic

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Hrdinka, M., Horejsi, V. PAG - a multipurpose transmembrane adaptor protein. Oncogene 33, 4881–4892 (2014). https://doi.org/10.1038/onc.2013.485

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