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It takes two to transport, or is it one?

Nature Structural & Molecular Biology volume 19, pages 129–130 (2012)Cite this article

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The proteins that 'pump' neurotransmitters into neurons, clearing the synapse after a nerve impulse, are central players in coherent brain function and are targets of many psychotropic drugs. Two groups now endeavor to resolve a fundamental controversy about how these proteins work. The results shed new light on the controversy but do not end it.

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Figure 1: Alternative symport mechanisms for LeuT.
Figure 2: Binding sites for substrates, drugs and detergents in LeuT.

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Authors and Affiliations

  1. Hyun-Ho Lim and Christopher Miller are in the Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts, USA.,

    Hyun-Ho Lim & Christopher Miller

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  1. Hyun-Ho Lim
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  2. Christopher Miller
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Correspondence to Hyun-Ho Lim.

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The authors declare no competing financial interests.

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Lim, HH., Miller, C. It takes two to transport, or is it one?. Nat Struct Mol Biol 19, 129–130 (2012). https://doi.org/10.1038/nsmb.2239

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