Oncogene-induced replication stress and DNA damage are among the hallmarks of cancer. A recent study explores how different levels of replication stress affect animal development and tumorigenesis, and how targeting of the replication stress–signaling pathway of ATR and Chk1 kinases can be exploited for selective killing of cancer cells.
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Acknowledgements
The authors are supported by grants from the Danish Cancer Society, the Danish National Research Foundation, the Czech Ministry of Health (NS10282-3/2009, NT11065-5/2010), the Czech Ministry of Education (MSM6198959216) and the European Commission (projects Infla-Care, Biomedreg and DDResponse).
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Bartek, J., Mistrik, M. & Bartkova, J. Thresholds of replication stress signaling in cancer development and treatment. Nat Struct Mol Biol 19, 5–7 (2012). https://doi.org/10.1038/nsmb.2220
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DOI: https://doi.org/10.1038/nsmb.2220
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