Many clear cell renal cell carcinomas (ccRCC) harbour ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) and protein polybromo-1 (PBRM1) mutations. Now, data from genetically modified mouse models indicate that conditional Bap1 or Pbrm1 knockout with Von Hippel–Lindau codeletion results in ccRCC of different grades: Bap1-deficient tumours had a higher grade with greater serine/threonine-protein kinase mTOR activation, relative to Pbrm1-deficient tumours, which had a longer latency.
References
Gu, Y.-F. et al. Modeling renal cell carcinoma in mice: Bap1 and Pbrm1 inactivation drive tumor grade. Cancer Discov. http://dx.doi.org/10.1158/2159-8290.CD-17-0292 (2017)
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Sidaway, P. Bap1 and Pbrm1 determine tumour grade. Nat Rev Urol 14, 391 (2017). https://doi.org/10.1038/nrurol.2017.84
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DOI: https://doi.org/10.1038/nrurol.2017.84