A new grading system for prostate cancer — which categorizes tumours from grade group 1 (least aggressive) to grade group 5 (most aggressive) — has been endorsed by the editors of five major urology journals.
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References
Epstein, J. I. et al. The 2014 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system. Am. J. Surg. Pathol. 40, 244–252 (2016).
Zeitman, A. et al. Consensus guidelines for reporting prostate cancer Gleason grade. Urology http://dx.doi.org/10.1016/j.urology.2016.03.002 (2016).
Gleason, D. F. & Mellinger, G. T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J. Urol. 111, 58–64 (1974).
Epstein, J. I. et al. The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma. Am. J. Surg. Pathol. 29, 1228–1242 (2005).
D'Amico, A. V. et al. Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer. JAMA 280, 969–974 (1998).
Pierorazio, P. M., Walsh, P. C., Partin, A. W. & Epstein, J. I. Prognostic Gleason grade grouping: data based on the modified Gleason scoring system. BJU Int. 111, 753–760 (2013).
Epstein, J. I. et al. A contemporary prostate cancer grading system: a validated alternative to the Gleason score. Eur. Urol. 69, 428–435 (2016).
Loeb, S. et al. Evaluation of the 2015 Gleason Grade Groups in a nationwide population-based cohort. Eur. Urol. 69, 1135–1141 (2016).
Berney, D. M. et al. Validation of contemporary prostate cancer grading system using prostate cancer death as outcome. Br. J. Cancer 114, 1078–1083 (2016).
Humphrey, P. A. et al. in WHO Classification of Tumours of the Urinary System and Male Genital Organs 4th edn (eds Moch, H. et al.) 138–162 (IARC Press, 2016).
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Epstein, J. Urology journals recommend new prostate cancer grade groups. Nat Rev Urol 13, 374–375 (2016). https://doi.org/10.1038/nrurol.2016.96
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DOI: https://doi.org/10.1038/nrurol.2016.96
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