Results from the analysis of DNA methylation patterns using Illumina HumanMethylation450 arrays showed no substantial differences between CD4+ T cells from 56 patients with oligoarticular juvenile idiopathic arthritis (JIA) and CD4+ T cells from 57 age-matched healthy individuals. The authors of the study suggest that this lack of a difference could indicate a less crucial role for epigenetic changes in JIA than in rheumatoid arthritis in adults.
References
Chavez-Valencia, R. A. et al. The DNA methylation landscape of CD4+ T cells in oligoarticular juvenile idiopathic arthritis. J. Autoimmun. http://dx.doi.org/10.1016/j.jaut.2017.09.010 (2017)
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Collison, J. DNA methylation in oligoarticular JIA. Nat Rev Rheumatol 13, 694 (2017). https://doi.org/10.1038/nrrheum.2017.177
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DOI: https://doi.org/10.1038/nrrheum.2017.177