Juvenile idiopathic arthritis

Definition

Juvenile idiopathic arthritis is an umbrella term for chronic autoimmune arthropathies of unknown aetiology with onset of symptoms before the age of 16 years. Comprising several clinically distinct subtypes, juvenile idiopathic arthritis is the most common form of childhood arthritis.

Latest Research and Reviews

  • Research | | open

    DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.

    • Nirit Mor-Vaknin
    • , Anjan Saha
    • , Maureen Legendre
    • , Carmelo Carmona-Rivera
    • , M Asif Amin
    • , Bradley J. Rabquer
    • , Marta J. Gonzales-Hernandez
    • , Julie Jorns
    • , Smriti Mohan
    • , Srilakshmi Yalavarthi
    • , Dave A. Pai
    • , Kristine Angevine
    • , Shelley J. Almburg
    • , Jason S. Knight
    • , Barbara S. Adams
    • , Alisa E. Koch
    • , David A. Fox
    • , David R. Engelke
    • , Mariana J. Kaplan
    •  & David M. Markovitz
  • Reviews |

    Macrophage activation syndrome (MAS) is a potentially fatal complication of rheumatic disease, most notably systemic juvenile idiopathic arthritis. Findings from studies in animal models and from clinical observations, particularly in relation to the effects of anticytokine biologic therapies, have led to new concepts of the pathophysiology of this phenomenon.

    • Alexei A. Grom
    • , AnnaCarin Horne
    •  & Fabrizio De Benedetti
  • Reviews |

    The most common form of eye inflammation associated with juvenile idiopathic arthritis (JIA) is chronic anterior uveitis, which, if inadequately treated, can lead to ocular complications, including blindness. Sen and colleagues discuss the epidemiology, immunopathogenesis and management of JIA-associated uveitis, and describe the potential for biomarkers to improve its treatment.

    • Ethan S. Sen
    • , Andrew D. Dick
    •  & Athimalaipet V. Ramanan
  • Reviews |

    The treatment of juvenile idiopathic arthritis (JIA) has improved markedly in past years, but sustained remission off-medication is still rare. In this Review, Hinze et al. discuss existing treatment approaches and guidelines, with a focus on targeted and patient-centred therapies developed to optimize management strategies for patients with JIA.

    • Claas Hinze
    • , Faekah Gohar
    •  & Dirk Foell
  • Reviews |

    Pain is a debilitating symptom of juvenile idiopathic arthritis (JIA) that can persist despite effective disease control. Insights into the underlying mechanisms of pain in JIA could highlight new treatment approaches and improve management. Here, the neurobiological basis of pain in JIA is described, using findings from animal models to inform the situation in humans.

    • Luke La Hausse de Lalouvi√®re
    • , Yiannis Ioannou
    •  & Maria Fitzgerald

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