A study that investigated links between juvenile idiopathic arthritis (JIA) and gut microorganisms found that circulating anti-lipopolysaccharide (anti-LPS) antibody concentrations were higher in patients with new-onset JIA, with no substantial intergroup differences between those with polyarticular JIA (n = 22), oligoarticular JIA (n = 31) or spondyloarthropathies (n = 16), than in healthy controls (n = 34). Circulating concentrations of LPS-binding protein and α-1-acid glycoprotein were also increased in patients with JIA and correlated with C-reactive protein levels as well as juvenile arthritis disease activity score.
References
Fotis, L. et al. Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis. J. Rheumatol. http://dx.doi.org/10.3899/jrheum.161589 (2017)
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Onuora, S. Evidence of gut-driven inflammation in new JIA. Nat Rev Rheumatol 13, 632 (2017). https://doi.org/10.1038/nrrheum.2017.168
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DOI: https://doi.org/10.1038/nrrheum.2017.168