The efficacy of treatment with a liposome-based steroid (methylprednisolone hemisuccunate (MPS)) nano-drug was superior to similar doses of free MPS in a mouse model of lupus. The steroid nano-drug, which was administered weekly, suppressed anti-double-stranded DNA antibody levels, renal damage and proliferation of lymphoid tissue, and prolonged the survival of the MRL-lpr/lpr mice, to a greater extent than treatment with daily injections of free MPS.
References
Moallem, E. et al. A liposomal steroid nano-drug for treating systemic lupus erythematosus. Lupus http://dx.doi.org/10.1177/0961203316636468 (2016)
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Onuora, S. Steroidal nano-drug suppresses murine lupus. Nat Rev Rheumatol 12, 252 (2016). https://doi.org/10.1038/nrrheum.2016.46
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DOI: https://doi.org/10.1038/nrrheum.2016.46