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Osteoarthritis

Epigenetics of articular cartilage in knee and hip OA

Nature Reviews Rheumatology volume 11, pages 6–7 (2015)Cite this article

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Epigenetic regulation is a vital driver of the aetiology of human disease, with research breakthroughs now occurring on a regular basis. Several studies investigating CpG methylation of cartilage DNA from patients with osteoarthritis are generating exciting insight into this common but complex disease.

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Acknowledgements

The authors acknowledge research support from Arthritis Research UK, the UK Medical Research Council (MRC), the Dr William Harker Foundation, the NIHR Newcastle Biomedical Research Centre and the European Union 7th Framework Programme (FP7/2007-2013) under grant agreement 305815 (D-BOARD). The authors are members of the MRC–Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA).

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  1. Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, 4th Floor Catherine Cookson Building, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK

    John Loughlin & Louise N. Reynard

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  1. John Loughlin
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  2. Louise N. Reynard
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Correspondence to John Loughlin.

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Loughlin, J., Reynard, L. Epigenetics of articular cartilage in knee and hip OA. Nat Rev Rheumatol 11, 6–7 (2015). https://doi.org/10.1038/nrrheum.2014.189

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