Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Connective tissue diseases

Management of lupus nephritis—new guidelines revealed

The past decade has seen exciting progress in the management of lupus nephritis, a manifestation of systemic lupus erythematosus that accounts for its major morbidity and mortality. The American College of Rheumatology has issued new guidelines for screening and treatment of lupus nephritis, based on expert recommendations.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Hahn, B. H. et al. American College of Rheumatology guidelines for screening, treatament, and management of lupus nephritis. Arthritis Care Res. 64, 797–808 (2012).

    Article  Google Scholar 

  2. Chan, T. M. et al. Long-term study of mycophenolate mofetil as continuous induction-maintenance treatment for diffuse proliferative lupus nephritis. J. Am. Soc. Nephrol. 16, 1076–1084 (2005).

    Article  CAS  Google Scholar 

  3. Houssiau, F. A. et al. Azathioprine versus mycophenolate mofetil for long-term immunosuppression in lupus nephritis: results from the MAINTAIN Nephritis Trial. Ann. Rheum. Dis. 69, 2083–2089 (2010).

    Article  CAS  Google Scholar 

  4. Dooley, M. A. et al. Mycophenolate versus azathioprine as maintenance therapy for lupus nephritis. N. Engl. J. Med. 365, 1886–1895 (2011).

    Article  CAS  Google Scholar 

  5. Ginzler, E. M. et al. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N. Engl. J. Med. 353, 2219–2228 (2005).

    Article  CAS  Google Scholar 

  6. Appel, G. B. et al. Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis. J. Am. Soc. Nephrol. 20, 1103–1112 (2009).

    Article  CAS  Google Scholar 

  7. Rovin, B. H. et al. Induction therapy in severe lupus nephritis: should MMF be considered the drug of choice? Clin. J. Am. Soc. Nephrol. (in press).

  8. Rovin, B. H. et al. Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study. Arthritis Rheum. 64, 1215–1226 (2012).

    Article  CAS  Google Scholar 

  9. Condon, M. B. et al. Treatment of class IV lupus nephritis with rituximab and mycophenolate mofetil (MMF) with no oral steroids is effective and safe (abstract). J. Am. Soc. Nephrol. 21 (Suppl.) 625A–626A (2010).

    Google Scholar 

  10. Dooley, M. A. Effect of belimumab treatment on renal outcomes: results from phase 3 belimumab clinical trials in patients with systemic lupus erythematosus (abstract). Arthritis Rheum. 63 (Suppl. S10), S963–S964 (2011).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ginzler, E. Management of lupus nephritis—new guidelines revealed. Nat Rev Rheumatol 8, 565–566 (2012). https://doi.org/10.1038/nrrheum.2012.131

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2012.131

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing