Seemingly, fracture risk in people aged ≥65 years is reduced by vitamin D supplementation, but only moderately and only at high doses (≥800 IU per day oral vitamin D). Data from 11 double-blind, randomized controlled trials were pooled in an analysis that included 31,022 people with 1,111 incident hip fractures and 3,770 nonvertebral fractures. Those in the highest quartile of intake had a 30% lower risk of hip fracture than those taking placebo (HR 0.70; 95% CI 0.58–0.86) and a 14% lower risk of any nonvertebral fracture (HR 0.86; 95% CI 0.76–0.96).
ORIGINAL RESEARCH PAPER
Bischoff-Ferrari, H. A. et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N. Engl. J. Med. 367, 40–49 (2012)
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Fracture prevention with high-dose vitamin D. Nat Rev Rheumatol 8, 500 (2012). https://doi.org/10.1038/nrrheum.2012.124
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DOI: https://doi.org/10.1038/nrrheum.2012.124