Microarray experiments performed in sural nerve biopsy samples have a uncovered a unique gene signature that characterizes progressing diabetic neuropathy. The study, published in Brain, identifed 532 genes that were differentially expressed between patients with progressing and non-progressing diabetic neuropathy. The investigators developed a computational model that incorporated 14 of these genes and could accurately classify the progression status in 92% of cases.
ORIGINAL RESEARCH PAPER
Hur, J. et al. The identification of gene expression profiles associated with progression of human diabetic neuropathy. Brain doi:10.1093/brain/awr228
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Progression-associated gene expression profiles in diabetic neuropathy. Nat Rev Neurol 7, 597 (2011). https://doi.org/10.1038/nrneurol.2011.172
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DOI: https://doi.org/10.1038/nrneurol.2011.172
